Protein Alignment SH3KBP1 and Abl

DIOPT Version :10

• Sequence 1: NP_001397685.1
• Gene: SH3KBP1 / 30011
• HGNCID: 13867
• Length: 709
• Species: Homo sapiens
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 147/736 - (19%)
• Similarity: 227/736 - (30%)
• Gaps: 248/736 - (33%)

Human   111 PQND---DELELKVGDII--EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQL 170
            |..|   |.||..:..:|  .|..:::.....|  .|..|:.|.               |..:..
  Fly   913 PDTDATGDSLEQSLSQVIAAPVTNKMQHSLHSG--GGGGGIGPR---------------SSQQHS 960

Human   171 SKSRPEGLPPASLLPFPAHGAKGKTTFEG--TILYRAAPGKTEGHRRYYSLRETTGSESDGGDSS 233
            |..||.|.        |..|.:|..|.:.  :.|:..|||.                    |..|
  Fly   961 SFKRPTGT--------PVMGNRGLETRQSKRSQLHSQAPGP--------------------GPPS 997

Human   234 STKSEGANGTVATA------AIQPKKVKGV--GFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGK 290
            :....|.||.|.:|      |:....||.|  .:|.:.|...|.....|:|..::..|.......
  Fly   998 TQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAP 1062

Human   291 KLPATT--ATPDSSKTEMDS---------RTKSKDYCKVIFPYEAQND-----DEL----TIKEG 335
            .||...  |||.:::....:         |:.|.....:      ||:     ::|    |..||
  Fly  1063 SLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTM------QNNAAASLNKLQRHRTTTEG 1121

Human   336 DIVTLINKDCIDVGWWEGELNGRRGV------------FPDNFVKLLPPDFEKEGNRPKKPPPPS 388
            .::|..:...  .|..........||            ||...:.|.||..|.||..|..||.|.
  Fly  1122 TMMTFSSFRA--GGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPE 1184

Human   389 APV----------------IKQGAGTTER---KHEIKKIPPERPEMLPNRTEEKERPEREPKLDL 434
            :.|                |..|.||...   .:::..|.|           ..|.......:.|
  Fly  1185 SAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAP-----------SVEEASSRFGVSL 1238

Human   435 QKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGD-SPKIDLAGSSLSGILD--- 495
            :|           |.|.|:|.|..|:.|....|:.:..:.....| :|...||..|...::|
  Fly  1239 RK-----------REPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVS 1292

Human   496 ---KDLSDRSN---------------DIDLEGFDSVVSSTE--KLSHPTTSRPKATGRRPPSQSL 540
               .:|::..|               :....||.:.:...|  |:|.|   .|||    .|:.::
  Fly  1293 LLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAP---MPKA----EPANTI 1350

Human   541 T--SSSLSSPDIFDSPSPEEDKEEHISLA-----------HRGVDASKKTSKT---------VTI 583
            .  .:.|...|....|:........:::|           :|..|.|||.|:.         ||.
  Fly  1351 IDFKAHLRRVDKEKEPATPAPAPATVAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKIDVTN 1415

Human   584 SQVSDNKASL------------------------PPKPG-----------TMAAGGGGPAPLSSA 613
            |.|..:..:.                        ||.|.           ::..|||.|....|.
  Fly  1416 SNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTILQQQPSVVNGGGTPNAQLSP 1480

Human   614 APSPLSSSLGTAGHRANSPSLFGTEGKPKMEP-----AASSQAAVEELRTQVRELRSIIETMKDQ 673
            .....|.::.|.|   ..|:..|.:..|...|     ..:|.::...:.|..|:.     |.:.|
  Fly  1481 KYGMKSGAINTVG---TLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSISTSSRDC-----TSRQQ 1537

Human   674 QKREIK-----QLLSELDEEK 689
            ....||     ||.:: |||:
  Fly  1538 ASSTIKTSHSTQLFTD-DEEQ 1557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3KBP1	NP_001397685.1	SH3_CIN85_1	3..55	CDD:212985
		SH3_CIN85_2	102..154	CDD:212988	11/47 (23%)
		SH3_CIN85_3	315..370	CDD:212990	12/75 (16%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645
		FABD	1584..1723	CDD:197885