DRSC/TRiP Functional Genomics Resources

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Protein Alignment SH3KBP1 and Btk

DIOPT Version :10

Sequence 1:NP_001397685.1 Gene:SH3KBP1 / 30011 HGNCID:13867 Length:709 Species:Homo sapiens
Sequence 2:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster


Alignment Length:234 Identity:51/234 - (21%)
Similarity:85/234 - (36%) Gaps:77/234 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   116 ELELKVGDIIEVVGEVEEGWWEGVLN--GKTGMFPSNFIKELSGESDELGISQDE----QLSKSR 174
            :|.|:.....||:.:.:|.||: |.:  |..|..|||::|..:    .||:.:.|    .:|:.|
  Fly   360 DLSLEKNAEYEVIDDSQEHWWK-VKDALGNVGYIPSNYVKPKA----LLGLERYEWYVGDMSRQR 419

Human   175 PEGLPPASLLPFPAHGAKGKTTFEGTILYRAAPGK-----------TEGHRRYYSLRETTGSE-- 226
            .|     |||   ..|.|     ||..:.|.:..|           .:.|.::|.:::....|  
  Fly   420 AE-----SLL---KQGDK-----EGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYY 471

Human   227 -------------------SDGGDSSSTKSEGANGTVATAA--------IQPKKVK-----GVG- 258
                               :.||.:...||...:..|...|        |.|.::.     |.| 
  Fly   472 LSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQ 536

Human   259 FGDIFK-------DKPIKLRPRSIEVENDFLPVEKTIGK 290
            ||.:.:       |..:|:.......|:||:...|.:.|
  Fly   537 FGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTK 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SH3KBP1NP_001397685.1 SH3_CIN85_1 3..55 CDD:212985
SH3_CIN85_2 102..154 CDD:212988 13/39 (33%)
SH3_CIN85_3 315..370 CDD:212990
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 13/39 (33%)
SH2_Tec_family 403..505 CDD:198188 22/114 (19%)
PTKc_Tec_like 521..778 CDD:173637 13/55 (24%)
Blue background indicates that the domain is not in the aligned region.

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