DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ext1 and sotv

DIOPT Version :9

Sequence 1:	NP_001124012.1	Gene:	Ext1 / 299907	RGDID:	1587375	Length:	746	Species:	Rattus norvegicus
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	237/734 - (32%)
Similarity:	373/734 - (50%)	Gaps:	112/734 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat    65 FFPWDQLENEDSSVHISPRQ-----KRDANSSIY------------------KGKKCRMESCFDF 106
            |..||        :..|||.     |||:::.|.                  :...|....|.:.
  Fly    44 FLLWD--------LSSSPRDGFFHGKRDSHTLILDLEHIQELAVNPEAEQRARNVNCTFWDCLNI 100

  Rat   107 TLCKKNGFKVYVYPQQK---------GEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLD 162
            ..|:.:..|||:||.|:         ...::..|..||.|:..||:|||:|::||||:.|||.|:
  Fly   101 YKCEHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLKSRYYTSNPNEACLFLPSLDLLN 165

  Rat   163 RDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFR 227
            ::....   |...:.:.||..|:.|.||:|||:..|..|.|...:..:...|::......:.::|
  Fly   166 QNVFDK---HLAGAALASLDFWDRGANHIIFNMLPGGAPSYNTVLDVNTDNAIIFGGGFDSWSYR 227

  Rat   228 PNFDVSIPLFS----KDHPRTGGERGFL----KFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALY 284
            |.|||:||::|    :.|.....:|.||    :.|.:|            |::.     |...|.
  Fly   228 PGFDVAIPVWSPRLVRQHAHATAQRKFLLVVAQLNILP------------RFVR-----TLRELS 275

  Rat   285 HVHNGEDVLLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLE 349
            ..|: |.:|||..|::     .....||.. :..::..:|..:|....|||:.|..|:|....:|
  Fly   276 LAHS-EQLLLLGACEN-----LDLTMRCPL-SQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDLVE 333

  Rat   350 ALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEA 414
            .:...|:||:..:.:.|||.:||:|:.|:|...|..|..:...:::|...||:.:::|.|:|:..
  Fly   334 IMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLFSK 398

  Rat   415 YFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNK---------HPGGLFVLPQYSSYLGDFPYYYA 470
            ||..::.:.||.||:::.|||...:|:|..||.         :|  || ||
  Fly   399 YFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNARSTFNP--LF-LP-------------- 446

  Rat   471 NLGLKPPSK-FTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAK-HRWPATA 533
              .|.|.|: |||||.....:.|....:.||.|..:    ...|:|:||..|..|.. ..:|:.:
  Fly   447 --SLAPKSQGFTAVILTYDRVESLFLLIQKLAVVPS----LQSILVIWNNQKKSPPHLSTFPSIS 505

  Rat   534 VPVIVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTT-EVDFAFTVWQSFPERIVGYPARSH 597
            .|:.:.:.:...:|:||.||..|.|:|:|::|:|.::.|| |:||.:.||:.||:.|||:|:|.|
  Fly   506 KPLKIRQTKENKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIH 570

  Rat   598 FWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVS 662
            .|:|...||.|.|:|||..||||||||.:|||:.::|:|.:|..:|:.||:..|||||.|||||:
  Fly   571 VWENVTMRWHYESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVA 635

  Rat   663 AVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPV 727
            .:|..||||||.:|::|......|...|  ||.:|..:|.:|::.|:..:|.|||...:.|.|||
  Fly   636 NITNNPPIKVTPRKKFKCPECTNTEMLS--ADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPV 698

  Rat   728 LFKDQVSILRKKYRDIERL 746
            ||:|......|:|.||..|
  Fly   699 LFRDNFPDKLKRYNDIGSL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ext1	NP_001124012.1	Exostosin	110..396	CDD:397245	85/302 (28%)
Ext1	NP_001124012.1	Glyco_transf_64	480..725	CDD:401264	101/246 (41%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	85/301 (28%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	99/239 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920