Protein Alignment GZMH and CG17234

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_722785.1
• Gene: CG17234 / 59225
• FlyBaseID: FBgn0042187
• Length: 251
• Species: Drosophila melanogaster
• Alignment Length: 266
• Identity: 76/266 - (28%)
• Similarity: 118/266 - (44%)
• Gaps: 52/266 - (19%)

Human     1 MQPFLLLLA--FLLTPGAG-----TEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDF 58
            ::.||||||  ||   .||     .:.||||........|:...:|:..:..   |||.:..::.
  Fly     3 IESFLLLLALDFL---SAGQVNRWEQRIIGGEPIGIEQVPWQVSLQYFGDHV---CGGSIYSENI 61

Human    59 VLTAAHC----QGSSIN-----VTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQL 114
            ::|||||    :|:.::     |..|: .:.:...|  .:.|...|.|..|......|||.:::|
  Fly    62 IVTAAHCFFDEEGNRLDDQGYQVRAGS-ALTDSNGT--LVDVAALIIHEEYAFDLNINDIAIVRL 123

Human   115 ERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWG--YV---SMSTLATTLQEVLLTVQKDCQCER 174
            ....::|:.|:|  :|.:|....|..:..|:|||  |:   |.:...|.||.:.|.::....| |
  Fly   124 STPLEFTSKVQP--IPLAKTNPYPRSIALVSGWGVSYILNDSTNLYPTHLQGLALHIKSIFSC-R 185

Human   175 LFH------GNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVS 233
            ||.      |.|.|             |...||||||||......|::|:|.|.......::.|.
  Fly   186 LFDPSLLCAGTYGR-------------TACHGDSGGPLVVNKQLVGVVSWGRKGCVSSAFFVSVP 237

Human   234 HFLPWI 239
            :|..||
  Fly   238 YFREWI 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	66/239 (28%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG17234	NP_722785.1	Tryp_SPc	27..243	CDD:238113	64/237 (27%)