Protein Alignment GZMH and CG10041

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_650177.2
• Gene: CG10041 / 41496
• FlyBaseID: FBgn0038014
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 249
• Identity: 69/249 - (27%)
• Similarity: 117/249 - (46%)
• Gaps: 31/249 - (12%)

Human    11 LLTPGAGTEEIIGGHEAKPHSRPYMAFV-QFLQEKSRKRCGGILVRKDFVLTAAHC----QGSSI 70
            ||.....|.::|   ..:|. .||:..: :.|:...:..|.|:::..:|||:||||    ....:
  Fly    33 LLATTVSTTKVI---SFRPR-YPYIVSIGENLKGYYKHLCVGVILSNEFVLSAAHCIQTNPTKQL 93

Human    71 NVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPL---RLPS- 131
            .|..||.::..:::|:.|:..:|  .||.:.... .|||.:|::..|.       ||   |..|
  Fly    94 YVAGGADSLNSRKQTRFFVVERR--WHPQFRVLG-GNDIAVLRIYPKF-------PLDDVRFRSI 148

Human   132 ---SKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKK 193
               .|.|...|...|:.|||.|.:..:....:...||::.| :|::.....:.:..:||....|.
  Fly   149 NFAGKPQRDSGTQASLVGWGRVGVGKIRKLQEMPFLTMEND-ECQQSHRFVFLKPLDICAMHLKG 212

Human   194 TQTGFKGDSGGPL--VCKDVAQGILSYGNKKGTP--PGVYIKVSHFLPWIKRTM 243
            .:....||||.||  |.|:...|:||||.|..||  |..:.:::.:..||:.:|
  Fly   213 PRGPCDGDSGAPLMNVAKEKLYGLLSYGRKACTPLKPYAFTRINAYSSWIQESM 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	65/236 (28%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG10041	NP_650177.2	Tryp_SPc	49..264	CDD:238113	63/226 (28%)