Protein Alignment GZMH and CG18179

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_648340.1
• Gene: CG18179 / 39124
• FlyBaseID: FBgn0036023
• Length: 268
• Species: Drosophila melanogaster
• Alignment Length: 274
• Identity: 70/274 - (25%)
• Similarity: 124/274 - (45%)
• Gaps: 47/274 - (17%)

Human     1 MQPFLLLLAFLL-----TPG-------------AGTE-EIIGGHEAKPHSRPYMAFVQFLQEKSR 46
            |:.|||.|:..|     :||             .|.| .|:.|:.|.....||:..:....:.|.
  Fly     1 MKLFLLTLSVALAVVAASPGFNRTSLLPQVTISEGAEGRIVNGYPAPEGKAPYIVGLLIRTDGSN 65

Human    47 KRC--GGILVRKDFVLTAAHCQGSS-INVTLGAH-----NIKEQERTQQFIPVKRPIPHPAYNPK 103
            ...  .|.::..|::||||||..:. :.:..|::     ..::..|...|      |.||.: |.
  Fly    66 SAAVGAGTIIASDWILTAAHCLTTDYVEIHYGSNWGWNGAFRQSVRRDNF------ISHPNW-PA 123

Human   104 NFSNDIMLLQLERKAKWTTAVRPLRLP--SSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTV 166
            ....||.|::.. ...:|..:..:.||  |.::.......|...|||.:....||..||.:.:.:
  Fly   124 EGGRDIGLIRTP-SVGFTDLINKVALPSFSEESDRFVDTWCVACGWGGMDNGNLADWLQCMDVQI 187

Human   167 QKDCQCERLFHGNYSRATEICVGDPKKT--QTGFKGDSGGPLVCKDVAQ--GILSYGNKK-GTPP 226
            ..:.:||:.: |..: :|::|.   ::|  ::...||||||||..|.|:  |::::|:.. .:.|
  Fly   188 ISNSECEQSY-GTVA-STDMCT---RRTDGKSSCGGDSGGPLVTHDNARLVGVITFGSVDCHSGP 247

Human   227 GVYIKVSHFLPWIK 240
            ..|.:|:.:|.||:
  Fly   248 SGYTRVTDYLGWIR 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	60/235 (26%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG18179	NP_648340.1	Tryp_SPc	40..263	CDD:238113	60/235 (26%)