Protein Alignment GZMH and CG10469

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_648025.1
• Gene: CG10469 / 38696
• FlyBaseID: FBgn0035678
• Length: 267
• Species: Drosophila melanogaster
• Alignment Length: 260
• Identity: 77/260 - (29%)
• Similarity: 127/260 - (48%)
• Gaps: 29/260 - (11%)

Human     5 LLLLAFLLTPG--AGTEEIIGGHEAKPHSRPYMAFVQFLQEKSR---KRCGGILVRKDFVLTAAH 64
            :|::.|.|..|  .|:..|:.|..||....||...:....|.|:   ..|||.::...:::||||
  Fly     6 VLIVQFSLVFGQETGSLRIMNGTAAKAKQLPYQVGLLCYFEGSKDEPNMCGGTILSNRWIITAAH 70

Human    65 C-QGSSIN---VTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVR 125
            | |....|   |.:....:|..:..:..:.....|.|..::.|..:|||.|::|.:|..:...::
  Fly    71 CLQDPKSNLWKVLIHVGKVKSFDDKEIVVNRSYTIVHKKFDRKTVTNDIALIKLPKKLTFNKYIQ 135

Human   126 PLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFH---GNYSRATE-- 185
            |.:|||:| :...|:...::|||..:....:..||.:...:..:.:|||.::   |..|:...
  Fly   136 PAKLPSAK-KTYTGRKAIISGWGLTTKQLPSQVLQYIRAPIISNKECERQWNKQLGGKSKKVVHN 199

Human   186 --ICVGDPKKTQTGF--KGDSGGPLVCKDVAQ---GILSY---GNKKGTPPGVYIKVSHFLPWIK 240
              ||: |.||   |.  :||||||:|..|.::   ||:|:   |..|...|.|..:||.:|.|||
  Fly   200 GFICI-DSKK---GLPCRGDSGGPMVLDDGSRTLVGIVSHGFDGECKLKLPDVSTRVSSYLKWIK 260

Human   241  240
              Fly   261  260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	72/242 (30%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/4 (0%)
CG10469	NP_648025.1	Tryp_SPc	23..259	CDD:214473	69/240 (29%)