Protein Alignment GZMH and CG6592

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_648016.1
• Gene: CG6592 / 38687
• FlyBaseID: FBgn0035669
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 263
• Identity: 78/263 - (29%)
• Similarity: 123/263 - (46%)
• Gaps: 27/263 - (10%)

Human     2 QPFLL------LLAFLLTPGA-GTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFV 59
            :|.:|      |:..:|..|| ..:.|.||....||..||...:...:.|....|||.|:....|
  Fly    97 EPLVLNLETTPLMEKMLPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYWCGGSLISDKHV 161

Human    60 LTAAHC--QGSSINVTLGAH---NIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAK 119
            :|||||  ......|.|||:   |.||:.:.:..:|.:....:|.:|||...:||.:::|.....
  Fly   162 ITAAHCVDMAKRALVFLGANEIKNAKEKGQVRLMVPSENFQIYPTWNPKRLKDDIAIVRLPHAVS 226

Human   120 WTTAVRPLRLPSSKAQVK--PGQLCSVAGWG-YVS-MSTLATTLQEVLLTVQKDCQCERLFHGNY 180
            :...:.|::||....:.:  ..:|...:||| |.: :..::..|:.|.|.:.....|:..|..:|
  Fly   227 FNERIHPIQLPKRHYEYRSFKNKLAIASGWGRYATGVHAISNVLRYVQLQIIDGRTCKSNFPLSY 291

Human   181 SRATEICVGDPKKTQTGFKGDSGGPLVC------KDVAQGILSYGNKKGTP---PGVYIKVSHFL 236
             |.|.||... :..::...||||||||.      |.|..||.|:|:..|..   |..:.||:.:|
  Fly   292 -RGTNICTSG-RNARSTCNGDSGGPLVLQRRHSKKRVLVGITSFGSIYGCDRGYPAAFTKVASYL 354

Human   237 PWI 239
            .||
  Fly   355 DWI 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	72/237 (30%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	72/237 (30%)