Protein Alignment GZMH and CG6462

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_648011.1
• Gene: CG6462 / 38681
• FlyBaseID: FBgn0035663
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 239
• Identity: 73/239 - (30%)
• Similarity: 117/239 - (48%)
• Gaps: 20/239 - (8%)

Human    21 IIGGHEAKPHSRPY-MAFVQFLQEKSRKRCGGILVRKDFVLTAAHCQGSSI--NVTLGAHNIKEQ 82
            |.||..|.....|| :..|..|......:|||.|:...||||||||...:|  .:..||....:.
  Fly    77 IAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIYTGATVFADV 141

Human    83 ERTQQFIPVKRP--IPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSS--KAQVKPGQLCS 143
            |.:.:.:.|...  |.:|.|......:|:.|::|.||.:.:..|:|:.|...  ......|::.:
  Fly   142 EDSVEELQVTHRDFIIYPDYLGFGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQNFLVGKVVT 206

Human   144 VAGWGYVSMST-LATTLQEVL---LTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGG 204
            ::||||:..|| ..|.|.:.|   :..|:.|.|..| .|..|:...:|. |....:....|||||
  Fly   207 LSGWGYLGDSTDKRTRLLQYLDAEVIDQERCICYFL-PGLVSQRRHLCT-DGSNGRGACNGDSGG 269

Human   205 PLV--CKDVAQ--GILSYGNKKGTP---PGVYIKVSHFLPWIKR 241
            |:|  .::|:.  |:.|:|:.:|..   |.||.:::.:||||::
  Fly   270 PVVYHWRNVSYLIGVTSFGSAEGCEVGGPTVYTRITAYLPWIRQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	73/239 (31%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	73/239 (31%)