Protein Alignment GZMH and CG3700

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_611736.1
• Gene: CG3700 / 37640
• FlyBaseID: FBgn0034796
• Length: 360
• Species: Drosophila melanogaster
• Alignment Length: 258
• Identity: 75/258 - (29%)
• Similarity: 108/258 - (41%)
• Gaps: 37/258 - (14%)

Human    18 TEEIIGGHEAKPHSRPYMAFVQFLQEKSRKR-----CGGILVRKDFVLTAAHC------------ 65
            |..|:||.:|.....|:||.:...:....|.     |||.:|...||||||||
  Fly    99 TPFIVGGTKASGKEFPFMALIGTHRPNKSKSDINWDCGGSVVHPKFVLTAAHCLETDESKAERLD 163

Human    66 ---QGSSINVTLGA--HNIKEQERTQQFIPVKRPIPHPAYNPKN----FSNDIMLLQLERKAKWT 121
               ......|.||.  :|....:...|...|...:.||.|:.::    |.|||.|::|:|||::.
  Fly   164 PNFDSPKFVVRLGELDYNSTTDDALVQDFRVVNYVVHPGYDTEDEEQGFKNDIALVELDRKAEFN 228

Human   122 TAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEI 186
            ..|..:.||....  ...|..:.||||:.:....::.|.:|.|....|..|::....:....|:.
  Fly   229 DHVAAVCLPPDSG--NDVQQVTAAGWGFTADGVKSSHLLKVNLQRFSDEVCQKRLRFSIDTRTQF 291

Human   187 CVGDPKKTQTGFKGDSGGPLV-------CKDVAQGILSYGNKKGTP--PGVYIKVSHFLPWIK 240
            |.|..........||||||:.       |.....||:|||...|:.  |.||.||..:..||:
  Fly   292 CAGSMSSQADTCNGDSGGPIFVQHPLYPCLKQVIGIVSYGLVCGSQGLPSVYTKVHLYTDWIE 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	74/255 (29%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG3700	NP_611736.1	Tryp_SPc	102..356	CDD:238113	74/255 (29%)