Protein Alignment GZMH and CG4927

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_001033953.1
• Gene: CG4927 / 36852
• FlyBaseID: FBgn0034139
• Length: 362
• Species: Drosophila melanogaster
• Alignment Length: 261
• Identity: 77/261 - (29%)
• Similarity: 110/261 - (42%)
• Gaps: 44/261 - (16%)

Human    18 TEEIIGGHEAKPHSRPYMAFVQFLQEKSRK---RCGGILVRKDFVLTAAHC-------------- 65
            |..|:||.:|.....|:||.:....:.|.:   .||.|::...||||||||
  Fly   102 TPFIVGGAKAAGREFPFMALLGQRGKNSSQIDWDCGAIIIHPKFVLTAAHCLETSETKEQRLDPN 166

Human    66 -QGSSINVTLGA--HNIKEQERTQQFIPVKRPIPHPAYNPKNFS----NDIMLLQLERKAKWTTA 123
             .|....|.||.  :|....:...|...|...:.||||...:.:    |||.:::||.:|.::..
  Fly   167 YDGPKYVVRLGELDYNSTTDDAQPQDFRVLNYVVHPAYGEDDDTGSRKNDIAVVELEMEATFSEY 231

Human   124 VRPLRLP----SSKAQVKPGQLCSVAGWGYVSMSTLATT-LQEVLLTVQKDCQCERLFHGNYSRA 183
            |.|..||    :.:.||      :.||||..|.|..|:: |.:|.|......:|.:.........
  Fly   232 VAPACLPLDGGNEQLQV------AAAGWGATSESGHASSHLLKVSLDRYDVAECSQRLEHKIDVR 290

Human   184 TEICVGDPKKTQTGFKGDSGGPLV-------CKDVAQGILSYGNKKGTP--PGVYIKVSHFLPWI 239
            |::|.|....:.....||||||:.       |.....||.|||...|..  |.||.||..:..||
  Fly   291 TQLCAGSRSTSADTCYGDSGGPVFVQHPIYSCLKQVIGITSYGLVCGVQGLPSVYTKVHLYTDWI 355

Human   240 K 240
            :
  Fly   356 E 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	76/258 (29%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/4 (0%)
CG4927	NP_001033953.1	Tryp_SPc	105..358	CDD:238113	76/258 (29%)