Protein Alignment GZMH and Ser6

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_523426.1
• Gene: Ser6 / 33073
• FlyBaseID: FBgn0011834
• Length: 259
• Species: Drosophila melanogaster
• Alignment Length: 277
• Identity: 72/277 - (25%)
• Similarity: 116/277 - (41%)
• Gaps: 69/277 - (24%)

Human     5 LLLLAFLL--------TPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLT 61
            :||.:|||        .||.....::||.:|..:..|:..   .|:......|||.::.:.::||
  Fly     8 ILLCSFLLFLVLPVQSAPGKLNGRVVGGEDAVKNQFPHQV---SLRNAGSHSCGGSILTRTYILT 69

Human    62 AAHC-QGSSIN---VTLGAHNIKEQERTQQ------FIPVKRPIPHPAYNPKNFSNDIMLLQLER 116
            |||| ....:|   ..:.|.....:..:..      .:.|...|.|..|.  ||.||:.||:||.
  Fly    70 AAHCVSNEDVNHVITPIAAERFTIRAGSNDRFSGGVLVQVAEVIVHEEYG--NFLNDVALLRLES 132

Human   117 KAKWTTAVRPLRLPS--SKAQVKPGQLCSVAGWG----------YVSMSTLATTLQEVLLTVQKD 169
            ....:.:::|:.||:  :.|.|.    ..::|||          |:..:||.:..::
  Fly   133 PLILSASIQPIDLPTVDTPADVD----VVISGWGRIKHQGDLPRYLQYNTLKSITRQ-------- 185

Human   170 CQCERL----FHGNYSRATEICVGDPKKTQTG-FKGDSGGPLVCKDVAQGILSY-----GNKKGT 224
             |||.|    |.|      |:|:  ..:...| ..||||||.|..:...|:..:     |:   |
  Fly   186 -QCEELIDFGFEG------ELCL--LHQVDNGACNGDSGGPAVYNNQLVGVAGFVVDGCGS---T 238

Human   225 PPGVYIKVSHFLPWIKR 241
            .|..|.:|.:|..|||:
  Fly   239 YPDGYARVFYFKDWIKK 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	65/253 (26%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	65/253 (26%)