Protein Alignment GZMH and CG9673

DIOPT Version :10

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_573149.1
• Gene: CG9673 / 32649
• FlyBaseID: FBgn0030775
• Length: 261
• Species: Drosophila melanogaster
• Alignment Length: 261
• Identity: 69/261 - (26%)
• Similarity: 118/261 - (45%)
• Gaps: 40/261 - (15%)

Human     5 LLLLAFLLTPGAGTE-EIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHC--- 65
            ||:...:|:..|..: .|:||.:......|:.|.|::   .....|.|.::..:.:||||||
  Fly    12 LLIFGLILSAEASPQGRILGGEDVAQGEYPWSASVRY---NKAHVCSGAIISTNHILTAAHCVSS 73

Human    66 ------QGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV 124
                  ..|::.|.||..|   |......:.||..|.||:|.  ||.:||.:|:|:....::..:
  Fly    74 VGITPVDASTLAVRLGTIN---QYAGGSIVNVKSVIIHPSYG--NFLHDIAILELDETLVFSDRI 133

Human   125 RPLRLPSS--------KAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYS 181
            :.:.||.:        .|::..|....|||||.:|..|.:...|:..........||  :...|.
  Fly   134 QDIALPPTTDEETEDVDAELPNGTPVYVAGWGELSDGTASYKQQKANYNTLSRSLCE--WEAGYG 196

Human   182 RATEICVGDPKKTQTGF-KGDSGGPLVCKD-VAQGILSY-----GNKKGTPPGVYIKVSHFLPWI 239
            ..:.:|:.  :....|. :||:|..::..| |.:|:.|:     |:|.   |.|..:||::|.||
  Fly   197 YESVVCLS--RAEGEGICRGDAGAAVIDDDKVLRGLTSFNFGPCGSKY---PDVATRVSYYLTWI 256

Human   240 K 240
            :
  Fly   257 E 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	65/244 (27%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG9673	NP_573149.1	Tryp_SPc	28..256	CDD:214473	63/242 (26%)