Protein Alignment GZMH and CG18420

DIOPT Version :9

• Sequence 1: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Sequence 2: NP_995715.1
• Gene: CG18420 / 2768924
• FlyBaseID: FBgn0028866
• Length: 299
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 74/281 - (26%)
• Similarity: 119/281 - (42%)
• Gaps: 62/281 - (22%)

Human     1 MQPFLLLLAF--------LLTPGAGTE-------EIIGGHEAKPHSRPYMAFV-----QFLQEKS 45
            |...||||..        .|....||.       .|:.|..|..:|.|:|||:     ||:
  Fly     8 MASILLLLTVFPLLGSTQFLDSECGTRSPLKLGPRIVNGKVAVRNSSPWMAFLHTSSNQFI---- 68

Human    46 RKRCGGILVRKDFVLTAAHC--QGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSND 108
               |||.|:.:..|||||||  ..::|.|.||.:|.|.:...::. .|.|...|..|:|...:||
  Fly    69 ---CGGTLISRRLVLTAAHCFIPNTTIVVRLGEYNRKLKGYREEH-QVNRTFQHRFYDPNTHAND 129

Human   109 IMLLQLERKAKWTTAVRPLRL---PSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDC 170
            |.||:|.....:...:||:.:   .|.|..:...::.:..|||.......::.|:.:.::.|...
  Fly   130 IALLRLVSNVVYKANIRPICIMWDASWKHHIDSIKVLTGTGWGRTESMHDSSELRTLDISRQPSK 194

Human   171 QC-------ERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPL--------VCKDVAQGILSYGN 220
            .|       .:...||::  :.:|:           ||:|||:        ..:.|..|| :..|
  Fly   195 MCAFGSVLSNQFCAGNWN--SNLCI-----------GDTGGPVGAMVRYRNAFRFVQVGI-AITN 245

Human   221 KKGTPPGVYIKVSHFLPWIKR 241
            |:...|.|:..|...:.:|:|
  Fly   246 KRCQRPSVFTDVMSHIEFIRR 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	66/246 (27%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
CG18420	NP_995715.1	Tryp_SPc	42..264	CDD:214473	64/243 (26%)
		Tryp_SPc	43..267	CDD:238113	66/246 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910