DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN1 and DSK2

DIOPT Version :10

Sequence 1:NP_038466.2 Gene:UBQLN1 / 29979 HGNCID:12508 Length:589 Species:Homo sapiens
Sequence 2:NP_014003.1 Gene:DSK2 / 855319 SGDID:S000004889 Length:373 Species:Saccharomyces cerevisiae


Alignment Length:569 Identity:138/569 - (24%)
Similarity:209/569 - (36%) Gaps:223/569 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    37 MKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGLT 101
            :.:.:|:.::|.|..|...|:|.||||.|:|..........||::||||||..|:..:.|.||.:
Yeast     3 LNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHS 67

Human   102 VHLVIKTQNRPQDHSAQQTNTA---GSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSS--- 160
            |||| |:|.:||..||...|.|   |:...|.:|||. |:..||..||        ||.|:|   
Yeast    68 VHLV-KSQPKPQTASAAGANNATATGAAAGTGATPNM-SSGQSAGFNP--------LADLTSARY 122

Human   161 ---LGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQS----MLSNPDLMRQLIMANPQMQ-- 216
               |.:.:.:.............:|.:.::::||||..||    |||||.::..:|.:|||:|  
Yeast   123 AGYLNMPSADMFGPDGGALNNDSNNQDELLRMMENPIFQSQMNEMLSNPQMLDFMIQSNPQLQAM 187

Human   217 -----QLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMY 276
                 |::| :|....||.|||::||:::.||                                 
Yeast   188 GPQARQMLQ-SPMFRQMLTNPDMIRQSMQFAR--------------------------------- 218

Human   277 TDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTAST 341
              :.:|  :|.....||...|.                    |.|...||:  :.|:.::.::|.
Yeast   219 --MMDP--NAGMGSAGGAASAF--------------------PAPGGDAPE--EGSNTNTTSSSN 257

Human   342 VGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQS 406
            .|...|:.| ||:..:.||.|             ...|||     ||.|                
Yeast   258 TGNNAGTNA-GTNAGANTAAN-------------PFASLL-----NPAL---------------- 287

Human   407 LSQNPDLAAQMMLNNPLF-AGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGL 470
                          ||.. |||     .....:|.|     :|..|::|..|..           
Yeast   288 --------------NPFANAGN-----AASTGMPAF-----DPALLASMFQPPV----------- 317

Human   471 QTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAG 535
                                             .|:.:|:|.|                      
Yeast   318 ---------------------------------QASQAEDTRP---------------------- 327

Human   536 VNPQLQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLL 584
                   ||.|::.||.||:.|||.:.:.|:.||..:||.:..|::.||
Yeast   328 -------PEERYEHQLRQLNDMGFFDFDRNVAALRRSGGSVQGALDSLL 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN1NP_038466.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
Ubl_PLICs 35..107 CDD:340506 28/69 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..145 14/37 (38%)
Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669 178..428 58/261 (22%)
STI1 182..219 CDD:128966 18/47 (38%)
STI1 212..256 CDD:450205 16/50 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..371 15/75 (20%)
STI1 390..422 CDD:128966 1/31 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..520 4/31 (13%)
UBA_PLICs 546..585 CDD:270582 16/39 (41%)
DSK2NP_014003.1 Ubl_Dsk2p_like 3..74 CDD:340523 29/71 (41%)
STI1 149..185 CDD:128966 15/35 (43%)
UBA_Dsk2p_like 328..369 CDD:270509 16/40 (40%)
Blue background indicates that the domain is not in the aligned region.

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