DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN1 and CG3223

DIOPT Version :10

Sequence 1:NP_038466.2 Gene:UBQLN1 / 29979 HGNCID:12508 Length:589 Species:Homo sapiens
Sequence 2:NP_649758.1 Gene:CG3223 / 40947 FlyBaseID:FBgn0037538 Length:415 Species:Drosophila melanogaster


Alignment Length:570 Identity:105/570 - (18%)
Similarity:182/570 - (31%) Gaps:228/570 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    58 VQQFKEEISKRFKSHTD--QLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQT 120
            |...|..::|......|  :|.:|..|::|:|.|||::     .|..:.||        |..|:.
  Fly    27 VAYLKAVVTKEMHLQFDASELEIIHHGRVLEDADTLNR-----TLQPNAVI--------HCFQKI 78

Human   121 NTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEM 185
            ......|..::..                             :||.:..||.|     |.|:.::
  Fly    79 KRYSPYVPPAAAE-----------------------------INTKHIQELFS-----LTSHLQI 109

Human   186 MVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQE 250
            .|....|...:.:...|:..|.|     ..|.|| |:..:.:||:.|::::..:           
  Fly   110 SVTSRFNILQKILAEYPEFRRNL-----GAQALI-RDSVLFNMLHEPEVVQNLV----------- 157

Human   251 MMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTE 315
                :|..|. .|:.|...:.:|:                       .|..|:|           
  Fly   158 ----KDYPLI-CEAAPFIVDTIRK-----------------------ELARNSS----------- 183

Human   316 NRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSL 380
                     |.|..:.:::.|.|:|....:.|:.:|.:.|.|:||.     ..|:..|.....:.
  Fly   184 ---------ATQLQEQAASESTTSSEEENSLGAGSSSSGGSSSTAV-----AAAAAANRRDEMAN 234

Human   381 LQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQM 445
            ::||:                                                 ||||...|..:
  Fly   235 IRQIS-------------------------------------------------RQQLANALANV 250

Human   446 QNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGG-SSGTNGSNATPSE 509
            ...::||.::...|.:|   :|...:...|.||....|...|.||..|:|. |||:..|....:|
  Fly   251 TPFNSLSNIAQRNADEA---VQGDERPRTTSAPLAGVGGAAGTGAGSSSGAISSGSISSELLRNE 312

Human   510 NTSPTAGTTEPGHQQFIQQMLQALAGVNP-QLQNPEV---------------------------- 545
                            :.:..|:|:...| .::|.||                            
  Fly   313 ----------------LARAFQSLSQDQPAPVENMEVESGEGPVPEQAATAPADDVDDEDDGGDD 361

Human   546 -----------RFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLL 584
                       ||.:||..::||||:|...|:..|..:.|::..||..|:
  Fly   362 SDVLPRRYRRHRFTEQLRTMAAMGFINHTQNVSYLELSDGNVEHAINLLM 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN1NP_038466.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
Ubl_PLICs 35..107 CDD:340506 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..145 3/34 (9%)
Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669 178..428 37/249 (15%)
STI1 182..219 CDD:128966 6/36 (17%)
STI1 212..256 CDD:450205 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..371 15/75 (20%)
STI1 390..422 CDD:128966 0/31 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..520 9/32 (28%)
UBA_PLICs 546..585 CDD:270582 15/39 (38%)
CG3223NP_649758.1 Ubl_ubiquitin_like 9..75 CDD:340559 16/60 (27%)
UBA_like_SF 373..410 CDD:473871 14/36 (39%)
Blue background indicates that the domain is not in the aligned region.

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