Protein Alignment UBQLN1 and ubqln1

DIOPT Version :10

• Sequence 1: NP_038466.2
• Gene: UBQLN1 / 29979
• HGNCID: 12508
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_989221.1
• Gene: ubqln1 / 394829
• XenbaseID: XB-GENE-986025
• Length: 564
• Species: Xenopus tropicalis
• Alignment Length: 583
• Identity: 450/583 - (77%)
• Similarity: 504/583 - (86%)
• Gaps: 25/583 - (4%)

Human    10 PPGSQDSAAGAEGAGAPAAAASAEP-KIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHT 73
            ||.|             :..:|::| :|:||||||||||||||||||||:::|||:|||||||.|
 Frog     4 PPSS-------------STPSSSDPARIIKVTVKTPKEKEEFAVPENSSIREFKEDISKRFKSST 55

Human    74 DQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNST 138
            :|||||||||||||||||||||||||||||||||||||.|..:|.|.:::.::.|.|:|.:|::|
 Frog    56 EQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRSQAATASQASSSSTSATNSTTSSSSTT 120

Human   139 SGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPD 203
            :.:.|..|.|||||||||||||||:|.:||||||||||:||:|||||||||||||||||||||||
 Frog   121 TTTTTGTPLGLGGLGGLAGLSSLGMNASNFSELQSQMQQQLMSNPEMMVQIMENPFVQSMLSNPD 185

Human   204 LMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGG 268
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   186 LMSQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGG 250

Human   269 YNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSS 333
            ||||||||||||||||:|||||||||||||||||.|:. |:|||||||||||||||||.:|.:.|
 Frog   251 YNALRRMYTDIQEPMLNAAQEQFGGNPFASLVSNASNA-GNQPSRTENRDPLPNPWAPPSSTAGS 314

Human   334 ASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAP 398
            .|:|:      |||:.::|:|..:||:..| |.:||.||||||||||:|||||||||||||||||
 Frog   315 TSTGS------TTGANSTGSSTTTTTSSTL-PNLGAGMFNTPGMQSLMQQITENPQLMQNMLSAP 372

Human   399 YMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQAL 463
            |||||||||||||:||||:|.|||||:||||||||||||||.||||||||:||||||||||||||
 Frog   373 YMRSMMQSLSQNPELAAQVMQNNPLFSGNPQLQEQMRQQLPFFLQQMQNPETLSAMSNPRAMQAL 437

Human   464 LQIQQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQ 528
            |||||||||||||||.|:|...|..|.|||...|..:..|:| |:||:||.:|.:||||||||||
 Frog   438 LQIQQGLQTLATEAPSLMPRTNPPFGGLGSPNSSPASVPSSA-PTENSSPLSGLSEPGHQQFIQQ 501

Human   529 MLQALAGVNPQLQ--NPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS 589
            |||||:|.|||.|  |||||||.||||||||||||||||||||||||||||||||||||||||
 Frog   502 MLQALSGANPQNQNPNPEVRFQPQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN1	NP_038466.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		5/25 (20%)
		Ubl_PLICs	35..107	CDD:340506	63/71 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..145		11/34 (32%)
		Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669	178..428		207/249 (83%)
		STI1	182..219	CDD:128966	35/36 (97%)
		STI1	212..256	CDD:450205	43/43 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..371		42/75 (56%)
		STI1	390..422	CDD:128966	28/31 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..520		13/31 (42%)
		UBA_PLICs	546..585	CDD:270582	37/38 (97%)
ubqln1	NP_989221.1	Ubl_PLICs	17..89	CDD:340506	63/71 (89%)
		STI1	194..238	CDD:450205	43/43 (100%)
		STI1	364..396	CDD:128966	28/31 (90%)
		UBA_PLICs	521..560	CDD:270582	37/38 (97%)