Protein Alignment UBQLN1 and ubqln4

DIOPT Version :10

• Sequence 1: NP_038466.2
• Gene: UBQLN1 / 29979
• HGNCID: 12508
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_998521.2
• Gene: ubqln4 / 334337
• ZFINID: ZDB-GENE-030131-6269
• Length: 599
• Species: Danio rerio
• Alignment Length: 622
• Identity: 398/622 - (63%)
• Similarity: 463/622 - (74%)
• Gaps: 76/622 - (12%)

Human    20 AEGAGAPAAA-------ASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLV 77
            ||.:|...|.       |:|...|:||||||||:|||.|:.|::||.|||||||||||:..||||
Zfish     2 AENSGTDPAVETNTEENAAASATIIKVTVKTPKDKEEIAIAEDASVAQFKEEISKRFKAKQDQLV 66

Human    78 LIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSST---PNSNSTS 139
            ||||||||||.|||.||||.|||||||||||        ||:|:.|||:.|::|:   |:..|.|
Zfish    67 LIFAGKILKDGDTLGQHGIKDGLTVHLVIKT--------AQKTSGAGSSQTSASSGPGPSQGSPS 123

Human   140 GSATSNPFG--------------------LGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPE 184
            |:.|.:|.|                    |.|.|.|:|||:||:.:.||.|||.||||||:||||
Zfish   124 GTDTPSPAGNLGTPQGSGPSPTPSQPANILAGFGDLSGLSNLGMGSANFMELQQQMQRQLMSNPE 188

Human   185 MMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQ 249
            |:.||||||.||||:||||||||:||||||||||::||||||||||||::||||:||||||||||
Zfish   189 MLSQIMENPLVQSMMSNPDLMRQMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQ 253

Human   250 EMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGE--GSQPS 312
            ||||||||||||||||||||||||||||||||||.|||:||||.|||::|..|   ||  |:|||
Zfish   254 EMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSALGGN---GENPGTQPS 315

Human   313 RTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQ-STTAPNLVPGVGASMFNTPG 376
            |||||:||||||.|....:|:.||||.:|...||.||....|.. ..::.||    |..|||:||
Zfish   316 RTENREPLPNPWGPPDGTASTTSSGTPTTTSSTTSSTTPSVSNPLGISSSNL----GNGMFNSPG 376

Human   377 MQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTF 441
            ||||:|||:|||||||||:||||||:|||||:||||:|:|:::||||||||||||||||||||.|
Zfish   377 MQSLMQQISENPQLMQNMISAPYMRTMMQSLAQNPDVASQVLMNNPLFAGNPQLQEQMRQQLPVF 441

Human   442 LQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLGALGSTGG---------- 496
            |||||||:.||.|:|||||:||:|||:|||||.||||||:||..||    |..||
Zfish   442 LQQMQNPEALSVMTNPRAMRALMQIQEGLQTLQTEAPGLMPGLGPG----GMPGGIPVGMPGAPL 502

Human   497 ---------SSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLE 552
                     :...:|..:||    :||||.: |..||.:|||||..||.:...|.||||||||||
Zfish   503 PTGVTVTPENPPPSGQGSTP----TPTAGAS-PAQQQLMQQMLQMFAGGSASTQTPEVRFQQQLE 562

Human   553 QLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS 589
            |||||||:|||||||||||||||||||||||||||||
Zfish   563 QLSAMGFINREANLQALIATGGDINAAIERLLGSQPS 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN1	NP_038466.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		6/21 (29%)
		Ubl_PLICs	35..107	CDD:340506	56/71 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..145		13/37 (35%)
		Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669	178..428		184/252 (73%)
		STI1	182..219	CDD:128966	31/36 (86%)
		STI1	212..256	CDD:450205	38/43 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..371		36/78 (46%)
		STI1	390..422	CDD:128966	23/31 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..520		10/50 (20%)
		UBA_PLICs	546..585	CDD:270582	37/38 (97%)
ubqln4	NP_998521.2	Ubl_PLICs	25..96	CDD:340506	56/70 (80%)
		rad23	26..311	CDD:273167	200/295 (68%)
		UBA_PLICs	556..595	CDD:270582	37/38 (97%)