Protein Alignment UBQLN1 and Ubqn

DIOPT Version :10

• Sequence 1: NP_038466.2
• Gene: UBQLN1 / 29979
• HGNCID: 12508
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_608344.1
• Gene: Ubqn / 32977
• FlyBaseID: FBgn0031057
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 289/576 - (50%)
• Similarity: 385/576 - (66%)
• Gaps: 59/576 - (10%)

Human    30 ASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQH 94
            |....|.:.|.|||||:|:...|.|:|.::.||..::::|::..:||||||||||:||.|||..|
  Fly     2 AEGGSKRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTDTLQMH 66

Human    95 GIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLS 159
            .|.|.||||||||...|..:..|:|                   .......||||...|||||:.
  Fly    67 NIKDNLTVHLVIKAPTRNNEQPARQ-------------------PADVRQTPFGLNQFGGLAGME 112

Human   160 SLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPE 224
            :||..:..|.:||::||.:||:|.:|:..:|:||.||.|::|||.|||||.:||||..|:|||||
  Fly   113 ALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPE 177

Human   225 ISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLSAAQE 289
            |||||||||::|||:||||||:|:||:||:.|||:|||||:||||:||:|:|.||||||::||.|
  Fly   178 ISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATE 242

Human   290 QFGGNPFASLVSNTSSGEGSQPSR-TENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGT 353
            .||.||||.||....||.|:.|.: ||||:||||||       ..|:|||..||||
  Fly   243 SFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPW-------GGANSGTNGTVGG--------- 291

Human   354 SGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAAQMM 418
            ||......:|.|.   ::.|||.|:|||||:.:||.:|||:|:|||.||||:|:||:||:||:::
  Fly   292 SGAGNPTGDLPPN---NVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAARLL 353

Human   419 LNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGL--- 480
            .::||.:.||.||||:||.:|.|:.|||||:.::.::||.||.|:||||||::.|.:.||||
  Fly   354 SSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGT 418

Human   481 --IPGFTPGLG-----ALG-STGGSSGTNGSNATPSENTSPTAGTTE--PG-------HQQFIQQ 528
              ||...||.|     |.| .:||:||.:.:|.:||...:...||..  ||       ...|:.:
  Fly   419 LGIPPPPPGAGTGTNPASGDGSGGNSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMR 483

Human   529 MLQALAGVNPQLQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLL 584
            ||..::......|.||||:|.|||||:||||:||:|||||||||.||||||:||||
  Fly   484 MLNGMSNNADNTQPPEVRYQSQLEQLNAMGFVNRDANLQALIATFGDINAAVERLL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN1	NP_038466.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		1/4 (25%)
		Ubl_PLICs	35..107	CDD:340506	38/71 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..145		3/34 (9%)
		Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669	178..428		141/250 (56%)
		STI1	182..219	CDD:128966	20/36 (56%)
		STI1	212..256	CDD:450205	33/43 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..371		31/76 (41%)
		STI1	390..422	CDD:128966	18/31 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..520		12/39 (31%)
		UBA_PLICs	546..585	CDD:270582	32/39 (82%)
Ubqn	NP_608344.1	Ubl_PLICs	7..79	CDD:340506	38/71 (54%)
		PABP-1234	<233..409	CDD:130689	98/194 (51%)
		UBA_PLICs	501..537	CDD:270582	28/35 (80%)