DRSC/TRiP Functional Genomics Resources

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Protein Alignment UBQLN1 and dsk2

DIOPT Version :10

Sequence 1:NP_038466.2 Gene:UBQLN1 / 29979 HGNCID:12508 Length:589 Species:Homo sapiens
Sequence 2:NP_594159.1 Gene:dsk2 / 2542667 PomBaseID:SPAC26A3.16 Length:354 Species:Schizosaccharomyces pombe


Alignment Length:565 Identity:120/565 - (21%)
Similarity:183/565 - (32%) Gaps:234/565 - (41%)


- Green bases have known domain annotations that are detailed below.


Human    37 MKVTVKTPK-EKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDTLSQHGIHDGL 100
            :.:|:|... :|....|...|||...||.|:.......::..||:||::|||:::|..:.|.||.
pombe     4 ISLTIKAANDQKYAVTVDSESSVLALKEAIAPVADIEKERQRLIYAGRVLKDEESLKTYKIQDGH 68

Human   101 TVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNT 165
            ::|||               .|.|.|...::|..|:.|....|:...|.|....||.|:|.....
pombe    69 SIHLV---------------KTLGQNPAAAATNVSDRTQQVPTNIQAGQGANNPLANLTSARYAG 118

Human   166 TNFSELQSQMQRQLLSNP-----EMMVQIMENPFVQS----MLSNPDLMRQLIMANPQM------ 215
            .|.....:.|......||     |.:..::.||.|||    |.|||.::..:|.::|.:      
pombe   119 FNIPMPSASMFGPNPENPVPPSTEELANMLSNPMVQSSINEMFSNPQMLDMIINSSPHLRNAPPY 183

Human   216 -QQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDI 279
             :|::| :||....:.:||.|||..:|            :|....:.:                 
pombe   184 VRQMMQ-SPEFRRAMTDPDTMRQMAQL------------HQQMGAAGI----------------- 218

Human   280 QEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGG 344
             :||              ||:.....|.|                                 :||
pombe   219 -DPM--------------SLMGGGLGGAG---------------------------------LGG 235

Human   345 TTGSTASGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQ 409
            ..|:...|..|    |.|...|:..                          :||..::...:..|
pombe   236 LGGAGLGGFGG----ANNATAGIAG--------------------------AAPVDQTAAANTIQ 270

Human   410 NPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLA 474
            |       :|||  ..|                                                
pombe   271 N-------LLNN--LGG------------------------------------------------ 278

Human   475 TEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQ 539
                   .||..|||..|...|..|. .|...|:::|.|                          
pombe   279 -------AGFGAGLGDAGLGAGLGGA-ASPPAPAQDTRP-------------------------- 309

Human   540 LQNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLL 584
               ||.|:.:||.||:.|||::.|.|:|||..:||::..|||.||
pombe   310 ---PEERYAEQLSQLNEMGFVDFERNVQALRRSGGNVQGAIESLL 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UBQLN1NP_038466.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
Ubl_PLICs 35..107 CDD:340506 24/70 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..145 7/34 (21%)
Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669 178..428 47/265 (18%)
STI1 182..219 CDD:128966 15/52 (29%)
STI1 212..256 CDD:450205 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..371 12/75 (16%)
STI1 390..422 CDD:128966 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..520 9/31 (29%)
UBA_PLICs 546..585 CDD:270582 20/39 (51%)
dsk2NP_594159.1 rad23 4..>169 CDD:273167 51/179 (28%)
Ubl_Dsk2p_like 4..74 CDD:340523 24/84 (29%)
UBA_Dsk2p_like 310..351 CDD:270509 20/40 (50%)
Blue background indicates that the domain is not in the aligned region.

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