Protein Alignment UBQLN1 and ubql-1

DIOPT Version :10

• Sequence 1: NP_038466.2
• Gene: UBQLN1 / 29979
• HGNCID: 12508
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_740883.1
• Gene: ubql-1 / 172434
• WormBaseID: WBGene00008852
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 218/566 - (38%)
• Similarity: 307/566 - (54%)
• Gaps: 76/566 - (13%)

Human    31 SAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRF-KSHTDQLVLIFAGKILKDQDTLSQH 94
            :.|..::||.||:|..|.:..:..::||.:.|:::.... .::.:|:.:|:.||||||::||:||
 Worm     2 ATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQH 66

Human    95 GIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGS---ATSNPF-GLGGLGGL 155
            .|.||.||||||:.|.||....|..|.||      ||.|:||.|..|   .|:||| .:||:|..
 Worm    67 KIADGHTVHLVIRNQARPTPAPAAATPTA------SSAPSSNPTPSSQPNPTNNPFAAMGGMGSP 125

Human   156 AGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQ 220
            |                     .:|:||:.|..:|:||..|.:|.||:.||.:|.:|||.|.||:
 Worm   126 A---------------------DILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIE 169

Human   221 RNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLS 285
            ||||:.|:||:|::||||:|:.|||.|.||||||.|:|:.||:.||||..||.|:|.|:|||:|:
 Worm   170 RNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLN 234

Human   286 AAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTA 350
            :|.....|||||||..:.||......:..||.:.||||||...:|:::..|...|....
 Worm   235 SATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFN------ 293

Human   351 SGTSGQSTTAPNLVPGVGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMMQSLSQNPDLAA 415
                               |:.::||:.||::|:..||.:..:|.|...:.|:.|::|.||.|..
 Worm   294 -------------------SLLDSPGISSLMEQMMSNPSMQASMFSPEVINSIRQNMSNNPGLID 339

Human   416 QMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGL 480
            .::...|....|||:.|.:|:..|..|..|.:|..:.||.|||..:|..|||:|..||..|||.|
 Worm   340 SIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMRNPRVSEAFRQIQEGFSTLRREAPQL 404

Human   481 IPGFTPGL---GALGS--TGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQL 540
            :..|..|.   ||.||  ...|:|.|.:|.......|...|...|.         ...|.|
 Worm   405 LNLFQAGAMGGGAFGSDANASSAGANSANGLADLFNSMNMGGGRPS---------STAAPV---- 456

Human   541 QNPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGS 586
             |||..:..|||||.:|||.:|..|:.||.||.||:|||:||||.|
 Worm   457 -NPEQTYASQLEQLQSMGFSDRARNVAALTATFGDLNAAVERLLNS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN1	NP_038466.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		1/3 (33%)
		Ubl_PLICs	35..107	CDD:340506	29/72 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..145		14/37 (38%)
		Interaction with UBXN4. /evidence=ECO:0000269|PubMed:19822669	178..428		98/249 (39%)
		STI1	182..219	CDD:128966	17/36 (47%)
		STI1	212..256	CDD:450205	29/43 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..371		18/75 (24%)
		STI1	390..422	CDD:128966	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..520		10/36 (28%)
		UBA_PLICs	546..585	CDD:270582	22/38 (58%)
ubql-1	NP_740883.1	Ubl_Dsk2p_like	8..80	CDD:340523	30/71 (42%)
		rad23	18..>372	CDD:273167	153/405 (38%)
		UBA_PLICs	461..500	CDD:270582	22/38 (58%)