Protein Alignment GYS1 and GSY2

DIOPT Version :10

• Sequence 1: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_013359.1
• Gene: GSY2 / 850962
• SGDID: S000004248
• Length: 705
• Species: Saccharomyces cerevisiae
• Alignment Length: 702
• Identity: 370/702 - (52%)
• Similarity: 480/702 - (68%)
• Gaps: 54/702 - (7%)

Human    23 DLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTP-- 85
            ||:|.:|||.|.||||:|||||:||::||.:|..::.|:|.|:||..:...:.:|::|:...|
Yeast     4 DLQNHLLFETATEVANRVGGIYSVLKSKAPITVAQYKDHYHLIGPLNKATYQNEVDILDWKKPEA 68

Human    86 ------ALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWY 144
                  .::..|.:|.|:|....:|||||||.|.|:|.|:.:.......|||:||....|..|..
Yeast    69 FSDEMRPVQHALQTMESRGVHFVYGRWLIEGAPKVILFDLDSVRGYSNEWKGDLWSLVGIPSPEN 133

Human   145 DREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLL 209
            |.|.|||:|.|:...||||| :|..:.:..:|||||||||||.|.|||.||:.|.||||||||||
Yeast   134 DFETNDAILLGYTVAWFLGE-VAHLDSQHAIVAHFHEWLAGVALPLCRKRRIDVVTIFTTHATLL 197

Human   210 GRYLCA-GAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRK 273
            |||||| |:.||||.||:.:||.|||...||||||:||||||.|.||||||||||.||:||||||
Yeast   198 GRYLCASGSFDFYNCLESVDVDHEAGRFGIYHRYCIERAAAHSADVFTTVSQITAFEAEHLLKRK 262

Human   274 PDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKG 338
            ||.:.||||||.||.|.||||||||..|.:|.:||||||:|..||:||.|||||||||||:.|||
Yeast   263 PDGILPNGLNVIKFQAFHEFQNLHALKKEKINDFVRGHFHGCFDFDLDNTLYFFIAGRYEYKNKG 327

Human   339 ADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRK 403
            ||:|:||||||||.|:|:||::|||||.:|||:.|:|.||.|||||..:.|.:|.:.|....|::
Yeast   328 ADMFIEALARLNYRLKVSGSKKTVVAFIVMPAKNNSFTVEALKGQAEVRALENTVHEVTTSIGKR 392

Human   404 LYESL-------LVGSLP-DMNKMLDKEDFTMMKRAIFATQRQ--SFPPVCTHNMLDDSSDPILT 458
            :::..       |...|| |:.::|...|..|:||.|.|.:|.  ..||:.||||:||::|.||.
Yeast   393 IFDHAIRYPHNGLTTELPTDLGELLKSSDKVMLKRRILALRRPEGQLPPIVTHNMVDDANDLILN 457

Human   459 TIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMG 523
            .||::.||||.:||||:|||||||::.:|:|.:||:|||||||||||||||||||||||||||||
Yeast   458 KIRQVQLFNSPSDRVKMIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMG 522

Human   524 IPSISTNLSGFGCFMEEHIADPSA--YGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQR 586
            :|||:||:||||.:||:.|....|  |||||:||||::.|:|..||..::..|.:::|||||.||
Yeast   523 VPSITTNVSGFGAYMEDLIETNQAKDYGIYIVDRRFKAPDESVEQLVDYMEEFVKKTRRQRINQR 587

Human   587 NRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFT----YEPNEA--DAAQG---YRYPRPASV 642
            |||||||||||||.:|..|:.||.:||.:.:|:.|.    .|.|::  ||..|   .:..||.||
Yeast   588 NRTERLSDLLDWKRMGLEYVKARQLALRRGYPDQFRELVGEELNDSNMDALAGGKKLKVARPLSV 652

Human   643 PPSPSLSRHSSP--------------HQSED---------EEDPRNGPLEED 671
            |.||...|.:|.              :.::|         .:|..:||..:|
Yeast   653 PGSPRDLRSNSTVYMTPGDLGTLQEVNNADDYFSLGVNPAADDDDDGPYADD 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	361/684 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		14/61 (23%)
GSY2	NP_013359.1	GT3_GSY2-like	7..616	CDD:340824	347/609 (57%)