Protein Alignment GYS1 and GSY1

DIOPT Version :10

• Sequence 1: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_116670.1
• Gene: GSY1 / 850569
• SGDID: S000001911
• Length: 708
• Species: Saccharomyces cerevisiae
• Alignment Length: 704
• Identity: 375/704 - (53%)
• Similarity: 491/704 - (69%)
• Gaps: 49/704 - (6%)

Human    23 DLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELL----EAP 83
            ||:|.:|||||.||.|:|||||:||::||.||..::||||.|:||..:....::||.|    |:.
Yeast     4 DLQNHLLFEVATEVTNRVGGIYSVLKSKAPVTVAQYGDNYTLLGPLNKATYESEVEKLDWEDESI 68

Human    84 TP----ALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWY 144
            .|    .:::||.||..||....:|.|||||.|.|:|.::.:....|..||.:||....|..|.:
Yeast    69 FPEELLPIQKTLMSMREKGVNFVYGNWLIEGAPRVILFELDSVRHFLNEWKADLWSLVGIPSPEH 133

Human   145 DREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLL 209
            |.|.|||:|.|::..||||| :::.:....::.|||||||||.|.|||.:|:.|.||||||||||
Yeast   134 DHETNDAILLGYVVVWFLGE-VSKLDSSHAIIGHFHEWLAGVALPLCRKKRIDVVTIFTTHATLL 197

Human   210 GRYLC-AGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRK 273
            ||||| ||.|||||||:.|:||:|||:|.||||||:||||||.|.||||||||||:||:||||||
Yeast   198 GRYLCAAGDVDFYNNLQYFDVDQEAGKRGIYHRYCIERAAAHTADVFTTVSQITALEAEHLLKRK 262

Human   274 PDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKG 338
            ||.:.||||||.||.|:||||||||..|.:|.:||||||:|..||:||.|:|||||||||:.|||
Yeast   263 PDGILPNGLNVVKFQAVHEFQNLHALKKDKINDFVRGHFHGCFDFDLDNTVYFFIAGRYEYKNKG 327

Human   339 ADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRK 403
            ||:|:|:||||||.|:|:||::|||||.||||:||:|.||.||.||:.|.|.:|.|.|....|::
Yeast   328 ADMFIESLARLNYRLKVSGSKKTVVAFLIMPAKTNSFTVEALKSQAIVKSLENTVNEVTASIGKR 392

Human   404 LYESL-------LVGSLP-DMNKMLDKEDFTMMKRAIFATQRQ--SFPPVCTHNMLDDSSDPILT 458
            ::|..       |...|| :::::|...:..::|:.:.|.:|.  ..|||.||||.||::||||.
Yeast   393 IFEHTMRYPHNGLESELPTNLDELLKSSEKVLLKKRVLALRRPYGELPPVVTHNMCDDANDPILN 457

Human   459 TIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMG 523
            .||.:.|||.|:||||||||||||::.:|:|.:||:|||||||||||||||||||||||||||||
Yeast   458 QIRHVRLFNDSSDRVKVIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYYEPWGYTPAECTVMG 522

Human   524 IPSISTNLSGFGCFMEEHIADPSA--YGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQR 586
            :|||:||:||||.:||:.|....|  |||||:||||:|.|:|..||..::..|..::|||||.||
Yeast   523 VPSITTNVSGFGAYMEDLIETDQAKDYGIYIVDRRFKSPDESVEQLADYMEEFVNKTRRQRINQR 587

Human   587 NRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNE--ADA-------AQGYRYPRPASV 642
            |||||||||||||.:|..|:.||.:.|.:|:||.|.....|  :||       .:.::..||.||
Yeast   588 NRTERLSDLLDWKRMGLEYVKARQLGLRRAYPEQFKQLVGETISDANMNTLAGGKKFKIARPLSV 652

Human   643 PPSPSLSRHSSPH---------QSEDEED-----PRNGPLEEDGERYDEDEEAA 682
            |.||.:..:|:.:         |..:..|     ..||.::.|    |:|.:.:
Yeast   653 PGSPKVRSNSTVYMTPGDLGTLQDANNADDYFNLSTNGAIDND----DDDNDTS 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	365/675 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		15/63 (24%)
GSY1	NP_116670.1	Glycogen_syn	12..683	CDD:399009	365/671 (54%)