Protein Alignment GYS1 and Glys

DIOPT Version :10

• Sequence 1: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_731967.2
• Gene: Glys / 41823
• FlyBaseID: FBgn0266064
• Length: 709
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 402/689 - (58%)
• Similarity: 522/689 - (75%)
• Gaps: 25/689 - (3%)

Human     3 LNRTLS-MSSLPGLEDWEDEFDL---ENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYF 63
            :||..| :.|...|:|:.|..|:   ||...|||||||||||||||||:::||.|:.:|.|:...
  Fly    21 MNRRFSRVESGADLKDYFDRGDIASRENRWNFEVAWEVANKVGGIYTVIRSKAYVSTEEMGEQLC 85

Human    64 LVGPYTEQGVRTQVELLEAP--TPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWAL 126
            ::|||.|...||::|.:|.|  .|.|. .::|:.|:|.|::.||||::|.|.::|.|:|::||.|
  Fly    86 MMGPYKEHCARTEMEEMEFPRGNPLLD-AVNSLRSRGYKIHTGRWLVDGNPQLILFDIGSAAWKL 149

Human   127 ERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEF------LAQSEE--KPHVVAHFHEWL 183
            :::|.|:|:.|:||:|..|.|.|||::.||:...||.||      .:|:.|  .|.:|||||||.
  Fly   150 DQFKSEMWEKCHIGIPHLDIETNDAIILGFMIAEFLEEFRNFAVTYSQNNELSAPRIVAHFHEWQ 214

Human   184 AGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAA 248
            |||||.:.|.|.:.:||:|||||||||||||||..||||||:.|.||:|||:||||||||:||.|
  Fly   215 AGVGLIVLRTRLVEIATVFTTHATLLGRYLCAGNTDFYNNLDKFAVDEEAGKRQIYHRYCLERGA 279

Human   249 AHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY 313
            .|.||||||||:||..||:|||||||||:||||||||||||:||||||||.:|.:|.||||||||
  Fly   280 THLAHVFTTVSEITGYEAEHLLKRKPDIITPNGLNVKKFSAIHEFQNLHAVAKEKINEFVRGHFY 344

Human   314 GHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVE 378
            ||:||:|||||||||||||||.|||||:|:|||||||.:|:....:.|||||.|.|.:||||||:
  Fly   345 GHIDFDLDKTLYFFIAGRYEFGNKGADIFIEALARLNAMLKHEKPDTTVVAFLIFPTKTNNFNVD 409

Human   379 TLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPV 443
            :|:|.||.|||.||.|.|::..|::::::.|.|::|:.:.:|.|:|...:||.:||.||.|.|||
  Fly   410 SLRGHAVIKQLRDTINNVQQAVGKRMFDTCLQGNIPNADDLLQKDDLVKIKRCMFAMQRDSMPPV 474

Human   444 CTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSY 508
            .|||:.||.:||:|::|||..||||..||||::||||||:||:||..:|||||||||||||||||
  Fly   475 TTHNVADDWNDPVLSSIRRCHLFNSRHDRVKMVFHPEFLTSTNPLFGIDYEEFVRGCHLGVFPSY 539

Human   509 YEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYS 573
            ||||||||||||||||||::||||||||||||||:||.:|||||:|||:..|::|..||:||:..
  Fly   540 YEPWGYTPAECTVMGIPSVTTNLSGFGCFMEEHISDPKSYGIYIVDRRYIGLENSVQQLSSFMME 604

Human   574 FCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPR 638
            |.:.:||||||||||||||||||||:.||.||..||..||...:|: :..|.:...:.....:.|
  Fly   605 FSRLNRRQRIIQRNRTERLSDLLDWRTLGIYYRQARVKALQAVYPD-YVDELSLYGSKNNLIFSR 668

Human   639 PASVPPSPSLSRHSSP----HQSEDEEDPRNGPLEEDGE 673
            |.|.||||:.|||::|    |.|:||:.     ::|:.|
  Fly   669 PHSEPPSPTSSRHTTPAPSVHGSDDEDS-----VDEETE 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	389/645 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		17/44 (39%)
Glys	NP_731967.2	Glycogen_syn	53..697	CDD:399009	389/650 (60%)