Protein Alignment GYS1 and Alg11

DIOPT Version :10

• Sequence 1: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_649340.1
• Gene: Alg11 / 40402
• FlyBaseID: FBgn0037108
• Length: 475
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 113/537 - (21%)
• Similarity: 179/537 - (33%)
• Gaps: 188/537 - (35%)

Human    46 VLQTKAKV-TGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIE 109
            :|..|.|: |..|.|.|..:..||...|...: .:|.....||:.          |....|.:|.
  Fly    29 LLGRKNKLHTSSENGINVGIFHPYCNAGGGGE-RVLWCAVRALQE----------KYQNARMVIY 82

Human   110 GGPLVVLLDVGASAWA-LERWKGELWDTCNIGVPWYDREANDAVLFGFLTT--WFLGEFLAQSEE 171
            .|      |:.||..: |::.|    :..||.|.      :|.|.|.||..  |.      :::.
  Fly    83 TG------DIDASPNSILQKAK----NVFNIAVD------SDNVKFVFLKQRHWI------EAKN 125

Human   172 KPHVVAHFHEWLAG-------VGL-CLCRARRLP----VATIFTTHATLLGRYLCAGAVDFYNNL 224
            .||..      |.|       ||| .||   |.|    :.|:.......|.|||....|..|.:.
  Fly   126 YPHFT------LLGQSIGSMVVGLEALC---RFPPDIYIDTMGYAFTYPLFRYLAQSKVGCYVHY 181

Human   225 ENFNVD--KEAGERQIYH---RY---------------------------CMERAAAHCA----H 253
            ...:.|  |...:||:.|   :|                           |.|....:.:    |
  Fly   182 PVISTDMLKRVQQRQMSHNNKKYVARNPFLTWTKLAYYRLFSRMYKWVGCCAETIMVNSSWTENH 246

Human   254 V-------FTT--------VSQITAIEAQHLLKRKPDIVTPNGLNVKKF----------SAMHEF 293
            :       |.|        ||.:.::  ||..|....|:    |:|.:|          .|::|.
  Fly   247 ILQLWDVPFKTHRVYPPCEVSHLKSL--QHTEKGDEFII----LSVGQFRPEKDHPLQLQAIYEL 305

Human   294 QNLHAQSKA---RIQEFVRGHFYGHLDF----NL-DKTLYFFIAGRYEFSNKGADVFLEALARLN 350
            :.|.||.:|   :|:..:.|......|:    |: |.|.:..:....:||   .:|..|.|.:|
  Fly   306 RTLLAQDEALWNQIKLVIVGSCRNEDDYERLKNMQDLTKHLSLENNVQFS---VNVPYEDLLKL- 366

Human   351 YLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPD 415
                               .:|.:..:.|         :|:      |.||..:.||:..|.:..
  Fly   367 -------------------YQTAHIGIHT---------MWN------EHFGIGIVESMAAGLIMV 397

Human   416 MNK----MLD-KEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKV 475
            .:|    :|| .|.....:....||....:    ..|:|    :.|:......|:.|::...|:.
  Fly   398 AHKSGGPLLDIVETSAGSQNGFLATDAVEY----AENIL----NIIVNNSEMNGIRNAARASVER 454

Human   476 I----FHPEFLSSTSPL 488
            .    |...||.:.|.|
  Fly   455 FSEQEFEKNFLRAVSTL 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	113/537 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737
Alg11	NP_649340.1	GT4_ALG11-like	44..463	CDD:340835	103/512 (20%)