DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GYS1 and PIG-A

DIOPT Version :9

Sequence 1:	NP_002094.2	Gene:	GYS1 / 2997	HGNCID:	4706	Length:	737	Species:	Homo sapiens
Sequence 2:	NP_001286547.1	Gene:	PIG-A / 37020	FlyBaseID:	FBgn0034270	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	79/341 - (23%)
Similarity:	121/341 - (35%)	Gaps:	110/341 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   196 LPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCME-----------RAAA 249
            |.:.|:||.| :|.|....:.|:.  |||...|:.      .:.|..|:.           |.|.
  Fly   113 LGLKTVFTDH-SLFGFADLSAALT--NNLLEVNLG------MVNHAICVSHIGKENTVLRARVAK 168

Human   250 HCAHV---------FTTVSQ-------ITAIEAQHLLKRKP-DIV---------TPNGLNV---- 284
            |...|         ||...|       |..:.|..|:.||. |::         ||| :|.
  Fly   169 HRVSVIPNAVDTALFTPDPQQRPSNDIINIVVASRLVYRKGIDLLAGIIPRFKNTPN-INFIIVG 232

Human   285 ------------KKFSAMHEFQNLHAQSKARIQEF-VRGHFYGHLDFNLDKTLYFFIAGRYEFSN 336
                        :|.:.....|.:.|....|:::| ||||.:  |:.:|.:.....|.   |.::
  Fly   233 DGPKRDLLEEIREKTNMQERVQMVGAVEHNRVRDFLVRGHIF--LNTSLTEAYCMAIV---EAAS 292

Human   337 KGADV-------FLEALARLNYLLRVNGSEQTVVAFF--IMPA----RTNNFNVETLKGQAVRKQ 388
            .|..|       ..|.|.:...||    :|..:.|.:  |:.|    |.::|.|....|..   .
  Fly   293 CGLQVVSTSVGGIPEVLPKSLILL----AEPEIDAIYAAILIAIDRHRKSSFKVSPSVGNG---H 350

Human   389 LWDTAN-TVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPV-CTH--NML 449
            |...|| .||.:..||:...:....||.::             |..|.|..|..|| |.:  |.|
  Fly   351 LASDANGKVKRRRRRKVDTPISPTQLPAVS-------------APPADQNSSTEPVMCPYRCNEL 402

Human   450 DDS----SDPILTTIR 461
            .::    .|..|.|::
  Fly   403 VETLYNWEDVALRTVK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:283373	79/341 (23%)
GYS1	NP_002094.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..737
PIG-A	NP_001286547.1	RfaB	1..309	CDD:223515	47/210 (22%)
PIG-A	NP_001286547.1	GT1_PIG-A_like	2..451	CDD:99970	79/341 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900