Protein Alignment GYS1 and gsy-1

DIOPT Version :10

• Sequence 1: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_496736.1
• Gene: gsy-1 / 174924
• WormBaseID: WBGene00001793
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 681
• Identity: 357/681 - (52%)
• Similarity: 471/681 - (69%)
• Gaps: 35/681 - (5%)

Human     1 MPLNRTLSMSSLPGL---EDWEDEFDL----------ENAVLFEVAWEVANKVGGIYTVLQTKAK 52
            ||  |.||.:.:...   ||.::|..|          |...:||.|||||||||||||||::||:
 Worm     7 MP--RNLSSNKIAKTIAGEDLDEEEVLEMDAGQSAREEGRFVFECAWEVANKVGGIYTVLRSKAQ 69

Human    53 VTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLL 117
            ::.:|.||.|.:.||..:...|.:|:.:|.....::..:....:.|.:..:|||||||.|.|:|.
 Worm    70 ISTEELGDQYCMFGPMKDGKWRLEVDPIEPENRTIRAAMKRFQADGFRCMYGRWLIEGYPKVILF 134

Human   118 DVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFL-AQSEEKPHVVAHFHE 181
            |:|:.|..:..||.||::.|.||:|..|.|:||||:.||:...||..|. :.:...|.|||||||
 Worm   135 DLGSGAVKMNEWKHELFEQCKIGIPHEDIESNDAVILGFMVALFLKHFRESVTSYTPLVVAHFHE 199

Human   182 WLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMER 246
            |.|||||.:.|..:|.:||::|||||||||:||||..|.||||::|::|.|||:|:|||:||:||
 Worm   200 WQAGVGLLMTRLWKLDIATVYTTHATLLGRHLCAGGADLYNNLDSFDLDAEAGKRKIYHQYCLER 264

Human   247 AAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGH 311
            ||...||:|||||:||.:||:|.|.||||::|||||||.||:|:|||||||||:|.:|.:|:|||
 Worm   265 AACQTAHIFTTVSEITGLEAEHFLCRKPDVLTPNGLNVVKFAALHEFQNLHAQNKEKINQFIRGH 329

Human   312 FYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQ----TVVAFFIMPART 372
            |:|||||:||||||||.||||||||||.|:|:|:|||||:.|:.....:    |||||.|.||..
 Worm   330 FHGHLDFDLDKTLYFFTAGRYEFSNKGGDMFIESLARLNHYLKTTSDPRHMGVTVVAFLIYPAPA 394

Human   373 NNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQR 437
            |:||||:||||||.|||.:..:.:|||.|:::::..|.|.||:..:::...|..::||.|.:...
 Worm   395 NSFNVESLKGQAVTKQLKEAVDRIKEKVGQRIFDICLQGHLPEPEELMSPADNILLKRCIMSLHN 459

Human   438 QSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHL 502
            .|.||:|||||: .:.||:|.::||..|||...|||||:||||||||.|||:.:|||:|||||||
 Worm   460 SSLPPICTHNMI-RADDPVLESLRRTSLFNKPEDRVKVVFHPEFLSSVSPLIGLDYEDFVRGCHL 523

Human   503 GVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQL 567
            ||||||||||||||||||||||||:|||||||||||:||:.|....|||::|||.::.::|..:|
 Worm   524 GVFPSYYEPWGYTPAECTVMGIPSVSTNLSGFGCFMQEHVEDHEQKGIYVIDRRHKAAEESVQEL 588

Human   568 TSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPE-HFTYEPNEADAA 631
            ...:|.||.||||||||.||..|.||.||||:.||.:|...|.:||.:..|: ......||...
 Worm   589 AQVMYDFCGQSRRQRIILRNSNEGLSALLDWQNLGVFYRDCRRLALERLHPDVDKIMRDNEGKV- 652

Human   632 QGYRYPRPASVPPSPSLSRHSSPHQSEDEED 662
                        ||.:.||..|.|.|:.|:|
 Worm   653 ------------PSAATSRRPSIHSSDGEDD 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	346/638 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		9/29 (31%)
gsy-1	NP_496736.1	Glycogen_syn	48..672	CDD:399009	346/638 (54%)