Protein Alignment NRBP1 and Madm

DIOPT Version :10

• Sequence 1: NP_001308287.1
• Gene: NRBP1 / 29959
• HGNCID: 7993
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_649581.1
• Gene: Madm / 40710
• FlyBaseID: FBgn0027497
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 280/576 - (48%)
• Similarity: 370/576 - (64%)
• Gaps: 63/576 - (10%)

Human     1 MSEGESQTVLSSGS---DPKVESSSSAPGLTSVS-----PPVTST----------------TSAA 41
            ||..::...:|..:   :|.....|.|.|..|.|     ||..||                :|||
  Fly     1 MSNSQANAGISGSTVADEPIQHHPSLAAGPVSASCPAATPPSQSTQQPPPHIVSASTADAGSSAA 65

Human    42 ----------------SPEEE-EESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTE 89
                            ||.|. ::||||||||||||||||.||||||:||:|||||..:||||||
  Fly    66 VGVGVVAGSEGVNLDSSPRESGDDSEDESEILEESPCGRWLKRREEVDQRDVPGIDCVHLAMDTE 130

Human    90 EGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKE-NKARVIFITEYM 153
            |||||||||||::..:..|.||||:|.|||||:||:|.||||||:||.|.:: .:.||:||||||
  Fly   131 EGVEVVWNEVQYASLQELKSQEEKMRQVFDNLLQLDHQNIVKFHRYWTDTQQAERPRVVFITEYM 195

Human   154 SSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI 218
            ||||||||||:||:|.|.:..::|:||||||||||||||||.|||||||||||:||||||||:||
  Fly   196 SSGSLKQFLKRTKRNAKRLPLESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKI 260

Human   219 GSVFHRIFANVAPDTINNHVKTC----REEQKNLHFF-APEYGEVTNVTTAVDIYSFGMCALEMA 278
            ||        |.||.::..|:..    ||.::..|:| |||||....:|.|:|||:|||||||||
  Fly   261 GS--------VVPDAVHYSVRRGRERERERERGAHYFQAPEYGAADQLTAALDIYAFGMCALEMA 317

Human   279 VLEIQ-GNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLK 342
            .|||| .|.||:.:.:|.|...|..||:.|||:.|:|||..:|..||:|.:|||||.||||.|||
  Fly   318 ALEIQPSNSESTAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPLLFEVHSLK 382

Human   343 LLAAHCIV---GHQHMIPENALEEITKN-MDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLE 403
            ||.|||:|   .::.|..|.|.:.:.:. .....|:|::....|:|....|...|.|.:|:||:|
  Fly   383 LLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAGGQERQYRLADVSGADKLEKFVE 447

Human   404 DVRNGIYPLTAFGLPRPQQPQ-QEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVK 467
            ||:.|:|||..:...:|  |. :....||....|||:.||||.:.|:|::|.|.|:::..|:...
  Fly   448 DVKYGVYPLITYSGKKP--PNFRSRAASPERADSVKSATPEPVDTESRRIVNMMCSVKIKEDSND 510

Human   468 HHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETL 523
            ..:|:||:::||:||.|:|.:..|:...:|.:|||:|||:...||.::..||||||
  Fly   511 ITMTILLRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLLEETL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRBP1	NP_001308287.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		38/109 (35%)
		PK_NRBP1	60..342	CDD:270936	180/288 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	417..445		10/28 (36%)
Madm	NP_649581.1	PK_NRBP1_like	114..376	CDD:270886	164/269 (61%)