Protein Alignment NRBP1 and Wnk

DIOPT Version :10

• Sequence 1: NP_001308287.1
• Gene: NRBP1 / 29959
• HGNCID: 7993
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_001262171.2
• Gene: Wnk / 40391
• FlyBaseID: FBgn0037098
• Length: 2462
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 153/547 - (27%)
• Similarity: 244/547 - (44%)
• Gaps: 111/547 - (20%)

Human     2 SEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQK 66
            ||..::....:||    .:.:||..|.|.|  :.||||:|:...:.:|:::.:.:..|||||:.|
  Fly   414 SEASAEEAAVTGS----STDASASPLPSTS--LVSTTSSATSITKSKSDEDDDPVAMSPCGRFFK 472

Human    67 RREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVK 131
            ..:||.:.:   ..:.|..:||..||.|.|.|:...:.|  |.:..:.|...|.|.:|:|.|||:
  Fly   473 YDKEVGRGS---FKTVYRGLDTLTGVPVAWCELLDKQVK--KSERTRFREEADMLKKLQHPNIVR 532

Human   132 FHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDP 196
            |:.||......|..::.:||.|.||:||.:||:.||.|    .|..|.||.|||..|::||:...
  Fly   533 FYTYWEFPIGRKKNIVLVTELMLSGTLKSYLKRFKKIH----PKVLKSWCRQILKGLNFLHTRQF 593

Human   197 PIIHGNLTCDTIFIQ-HNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNL----HFFAPEYG 256
            ||||.:|.||.|||. ..|.:|||        ::...|:.|     |...|::    .|.|||..
  Fly   594 PIIHRDLKCDNIFITGTTGSVKIG--------DLGLATLKN-----RSHAKSVIGTPEFMAPEMY 645

Human   257 EVTNVTTAVDIYSFGMCALEMAVLEI---QGNGESSYVPQEAIS----SAIQLLEDPLQREFIQK 314
            | .:...:||:|:||||.||||:.|.   :..|.:. :.::.||    :|:..:|||..|:.|::
  Fly   646 E-EHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQ-IYKKVISGIKPAALAKVEDPNVRDIIER 708

Human   315 CLQSEPARRPTARELL------------FHPALFEV----PSLKLLAAHC--------------- 348
            |::.:...||:..|||            ..|...|.    ||:.::....
  Fly   709 CIELKKEDRPSCNELLESEFFDEDIGIRVEPTASEQFLSDPSISIIEFRLRFMDPKKRSSRHKEN 773

Human   349 -IVGHQHMIPENALEEITKNM--------DTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLED 404
             .:..::.|..:..|:|.:.|        |.|..:|.:.    :..|.:|..:....:....|::
  Fly   774 EAIQFEYNIRHDEYEQIAQEMMKENIISEDDSRAVARLL----KVQVVSLLKERAQRQTQIKLQN 834

Human   405 VRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHH 469
            .::.:..|..       |.|:|         |:.|...|..|.|...        |..|:|||.:
  Fly   835 EKSRLEKLAL-------QKQRE---------SLPTNVDEDEEEEEES--------EDEEDGVKWN 875

Human   470 LTLLLKLEDKLNRHLSCDLMPNENIPE 496
            ..|.|:. |.||......|..:.|..|
  Fly   876 QRLQLRY-DLLNTDSETSLALSTNSVE 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRBP1	NP_001308287.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		21/67 (31%)
		PK_NRBP1	60..342	CDD:270936	105/309 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	417..445		6/27 (22%)
Wnk	NP_001262171.2	STKc_WNK	469..729	CDD:270885	98/283 (35%)
		OSR1_C	754..816	CDD:463491	7/65 (11%)
		DUF5585	1789..2159	CDD:465521