Protein Alignment POMT2 and PMT2

DIOPT Version :10

• Sequence 1: XP_047287268.1
• Gene: POMT2 / 29954
• HGNCID: 19743
• Length: 826
• Species: Homo sapiens
• Sequence 2: NP_009379.2
• Gene: PMT2 / 851210
• SGDID: S000000021
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 839
• Identity: 277/839 - (33%)
• Similarity: 410/839 - (48%)
• Gaps: 130/839 - (15%)

Human    11 ESELRPRRG---RCGPQAARAAGRDVAAEAVARSPKRPAWGSR--RFEAVGWWALLALVTLLSFA 70
            |:.||.|..   ....:.:.|..||    |...|.::||..|.  |.|:|   .:..:.|.|:..
Yeast    20 ENTLRQRESSSISVSEELSSADERD----AEDFSKEKPAAQSSLLRLESV---VMPVIFTALALF 77

Human    71 TRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDK 135
            ||.:::....|:.|||.||||.||||:...|:.||||||||||:||:|||:||:|::.|.. |:.
Yeast    78 TRMYKIGINNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPS-GEI 141

Human   136 Y-EHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPIL 199
            | ::..|:.||.|.|...:..||.||.|...:..||....|...|:.|:....||.::||||.:|
Yeast   142 YPDYLDYVKMRLFNASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSML 206

Human   200 MFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYL 264
            :||.:|:..|.|.:::...:|||..||.||.:||:||...:.||.||||||..||:.|:.|||..
Yeast   207 LFFTVASFFSFVMFHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTF 271

Human   265 FGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLH 329
            ..|.|:|..|...|..||:..||::|..::...|.:||.:||.||.||....|.|||||.|:::.
Yeast   272 LADKSMSWKTYINHWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVGSDVG 336

Human   330 NASIPEHLAYG-SVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTN 393
            ..  |..:|.| ||:::||..:....||||...||:  |:.|||||.|.:||.||.|...:....
Yeast   337 QG--PRDIALGSSVVSIKNQALGGSLLHSHIQTYPD--GSNQQQVTCYGYKDANNEWFFNRERGL 397

Human   394 SDPLDPSFPVEFVRHGDIIRLEHKECPLKKIWRWEQKETSRNLHSHYHEAPMTRKHYQVTGYGIN 458
            ....:....:|:::.|...||.|             |.|.||||:|...||:::..::|:|||.|
Yeast   398 PSWSENETDIEYLKPGTSYRLVH-------------KSTGRNLHTHPVAAPVSKTQWEVSGYGDN 449

Human   459 GTGDSNDFWRIEVVNRKFGN----RIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTC-- 517
            ..||:.|.|.||::::: |:    ::..|.:..|..:|..||.|..:|..||:||:.|.||.|
Yeast   450 VVGDNKDNWVIEIMDQR-GDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMK 513

Human   518 TPYLKETLNSIWNVEDHINPKLPNISLDVLQP--SFPEILLESHMVMIRGNSGLKPKDNEF---T 577
            .|: |....:.||:|.|.|.:||....|...|  :|.:..:..::.|:..|:.|.|..::|   .
Yeast   514 NPF-KRDKRTWWNIETHENERLPPRPEDFQYPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLA 577

Human   578 SKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEV 642
            |..|.||....|||..|..|.:.:.:|||.|...|.:.:::..::.:..|:.:..||
Yeast   578 SSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPASTWASSVAVLAFMATVVILLIRWQR-------- 634

Human   643 AGQVLWALPPLTWRQQGTCTPGEGRLPADGPSFAFTTPHLPLSFAFERKPRNHEIKKLAPGHTAR 707
                                                      .:...|.|.|.
Yeast   635 ------------------------------------------QYVDLRNPSNW------------ 645

Human   708 LSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWP 772
              .|.|.||...||.|.|||.||.:|.||.|.|||.||:.|:.::....:|.       ||..|.
Yeast   646 --NVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCFDA-------GLQKWS 701

Human   773 ------LARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWD 825
                  :.|.:..||.::|::|   .|:.|.|:::||.|     |.|....|.|..:||
Yeast   702 RSKCGRIMRFVLYAGFMALVIG---CFWYFSPISFGMEG-----PSSNFRYLNWFSTWD 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POMT2	XP_047287268.1	PMT	62..306	CDD:396786	103/244 (42%)
		beta-trefoil_MIR_POMT2	337..536	CDD:467753	71/205 (35%)
		PMT_4TMC	555..822	CDD:465056	66/275 (24%)
PMT2	NP_009379.2	PMT	69..313	CDD:396786	103/244 (42%)
		beta-trefoil_MIR_PMT2-like	339..531	CDD:467755	72/208 (35%)
		PMT_4TMC	550..749	CDD:465056	66/277 (24%)