Protein Alignment POMT2 and tw

DIOPT Version :10

• Sequence 1: XP_047287268.1
• Gene: POMT2 / 29954
• HGNCID: 19743
• Length: 826
• Species: Homo sapiens
• Sequence 2: NP_569858.1
• Gene: tw / 31024
• FlyBaseID: FBgn0086368
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 404/831 - (48%)
• Similarity: 523/831 - (62%)
• Gaps: 97/831 - (11%)

Human    16 PRRGRCGPQAARAAGRDVAAEAVARSP---KRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLD 77
            ||||         :.:|||..|...:|   |...|        .||.|||.|.|::|||||:::.
  Fly    12 PRRG---------SVKDVAQNAPRTAPTSSKEANW--------NWWLLLATVFLVTFATRFYKVT 59

Human    78 EPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYM 142
            ||.||||||||||||||:|||||||||||||||||||||:|||:||:|||.|:||||||....|.
  Fly    60 EPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPGDKYNETRYQ 124

Human   143 GMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAM 207
            |||.||..||:.::|..:.||.||::|..||||.||.|.||.|.|||:|||||||||:||:||::
  Fly   125 GMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDPILLFFMMASV 189

Human   208 LSMVKY--NSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSL 270
            ..|||.  ::.:...:...||.||.|||..|:..:.|||||||::|.|||:|..:||.:.|||..
  Fly   190 WGMVKVSKSTASGGSYGLRWWLWLFLTGTMLSCTISVKFVGLFVVLLVGLHTATELWLILGDLGQ 254

Human   271 SLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPE 335
            .::...|.|..|.:.|||.|:.||...|.:|..||::||.||||:|||||:||.||:|:|||:|.
  Fly   255 PILETVKQLACRAITLIVWPVLLYILFFYIHLSVLNRSGNGDGFYSSAFQSRLIGNSLYNASMPR 319

Human   336 HLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPS 400
            .:||||::|:||.:...||||||.||||:|.||||||||||.|||.||.|:|:.||   .|..|.
  Fly   320 DVAYGSLVTIKNHKTGGGYLHSHHHLYPKGSGARQQQVTTYTHKDENNKWLIRPHN---KPGPPK 381

Human   401 FPVEFVRHGDIIRLEHKECPLKKIWRWEQKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSND 465
            ..|:.:||||::||.|             ..|.||||||...||||:||.||||||..|.||:||
  Fly   382 GKVQILRHGDLVRLTH-------------MATRRNLHSHNEPAPMTKKHLQVTGYGELGLGDAND 433

Human   466 FWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWN 530
            .||:.:|..|....:..:.||::||||:..|.|.||||.|||||:||.||:|.|.:::. ||.||
  Fly   434 VWRVLIVGGKVNETVHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQQEVSCNPNVRDK-NSQWN 497

Human   531 VEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGV 595
            |||:.:..:|::|..|..|.|....||||.||::||:|||||:.|.||:||.|||||:|..|||
  Fly   498 VEDNEHKLMPSVSFSVYAPGFFARFLESHAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFFSG- 561

Human   596 NDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGQVLWALPPLTWRQQ-- 658
              :.:|:||||||::||.||:.:||::......||..||.|.. |..|.|....:|......|
  Fly   562 --SSYRIYLLGNPLIWWSNLVFLALFVTVFLCNAVVQQRRAGF-ARSAAQNQAQVPDSETVAQDE 623

Human   659 ----------GTCTPGEGRLPADGPSFAFTTPHLPLSFAFERKPRNHEIKKLAPGHTARLSQVLL 713
                      ..|||.:..:|...||.:...|:                    |..:       |
  Fly   624 ESEHSTTDICSCCTPAKEIVPKAVPSGSPEAPN--------------------PAQS-------L 661

Human   714 RGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIH 778
            |....:.|||.|||.||:.|||||||||||||::|:|:|||::::.:||:    |..|     ||
  Fly   662 RAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVMYNYILRV----LPKW-----IH 717

Human   779 --VAG-ILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF 826
              :.| :||:|:   |||..|.||||||.||||.:|.|.|..|:||.:|:|
  Fly   718 HVILGLVLSILV---YSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWEF 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POMT2	XP_047287268.1	PMT	62..306	CDD:396786	140/245 (57%)
		beta-trefoil_MIR_POMT2	337..536	CDD:467753	105/198 (53%)
		PMT_4TMC	555..822	CDD:465056	115/281 (41%)
tw	NP_569858.1	PMT	44..290	CDD:396786	140/245 (57%)
		beta-trefoil_MIR_POMT2	321..503	CDD:467753	105/198 (53%)
		PMT_4TMC	520..761	CDD:465056	115/283 (41%)