DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKN3 and Pkn

DIOPT Version :9

Sequence 1:	XP_006717143.1	Gene:	PKN3 / 29941	HGNCID:	17999	Length:	896	Species:	Homo sapiens
Sequence 2:	NP_001097237.1	Gene:	Pkn / 35950	FlyBaseID:	FBgn0020621	Length:	1501	Species:	Drosophila melanogaster

Alignment Length:	1374	Identity:	462/1374 - (33%)
Similarity:	609/1374 - (44%)	Gaps:	513/1374 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    24 EDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLP 88
            |:.||.|||.|:||||||||.|.||.||.|||.|..|..|::.|..:|.:|..||:||.::|||.
  Fly   133 EEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVLVKKSKSKLAELKSELQELESQILLT 197

Human    89 GP-----------------------------GPGPAEPVASGPRPWAEQLRARHLEALRRQLHVE 124
            ..                             |.|.......|..|  .....:.|.:|.:||.:|
  Fly   198 SANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTALEGGAP--ATANDKVLASLEKQLQIE 260

Human   125 LKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKI----------SSLEAS--- 176
            :|||.|||||..:...|.  ::||||.|.|||.||:.|:..||::|          ..|:||
  Fly   261 MKVKTGAENMIQSLGIGC--DKKLLAEAHQMLADSKAKIEFLRLRIIKVKQNREQADRLKASRQM 323

Human   177 ---------GSPEPGPELL-------AEELQHRLHVEAAVAEGAKNVVKLL-SSRRTQDRKALAE 224
                     |:....|:.|       .|||:|||.:||||.:|||||::.| ::.|..|:|||.|
  Fly   324 IDEHGQTIGGNNSSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQE 388

Human   225 AQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELR-AAVPGYPQP-------------- 274
            |..:|.|||:||||||.:|:...::||...|...::..||: ..:...|.|
  Fly   389 AHGRLSESSRKLDLLRYSLDLRRQELPADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGIL 453

Human   275 SGTPVKP-------TALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRG- 331
            .|.|.:.       .::||.|:||||||:.||..||||| .....::.|.|.||:..|....|.
  Fly   454 GGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRS-RRDKDNNSSPGDLRSFVKGVTSRSS 517

Human   332 --------ELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLC 388
                    |.:.|::||:|:||..||||.|.|.::|:|||.|.|.|:|:|||||||:|||||.||
  Fly   518 SKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLC 582

Human   389 GVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQ 453
            .|..||||:|:|:..|.::|.|.|||||||:|.|.:|:|.::|:|:||..||::::.::..||.|
  Fly   583 AVKVLRLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRAKQ 647

Human   454 MNLGMAAWGRLV----------------------------------------------------- 465
            ||:.:|.||||:
  Fly   648 MNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYT 712

Human   466 ----------------------------------------------MNLLPP------------- 471
                                                          :::|||
  Fly   713 PGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRP 777

Human   472 --------------------CSSPSTISPP----KGCPRT-----------------------PT 489
                                .::|:|..||    |....|                       ||
  Fly   778 NTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATSTTPILDQELQDALHEFDFLSDLDSRPT 842

Human   490 TLR---------------------------------------------EAS------------DP 497
            |||                                             ||.            :|
  Fly   843 TLRRLLKEQKMALDAGALENLLLQQQQTEQQALQQRQRQEQLRLQQFQEAQRQAILDLCVKQREP 907

Human   498 A-----TPSNFLPKKTPLGEEMTPP--------------------PKPPRLYLPQEPTSEETP-- 535
            |     |.:|..|...||......|                    |:||  :..|:||:.|.|
  Fly   908 AEQTSPTLANQTPTFPPLASNQIMPSLNARPCQSQSPNHNEFQLQPQPP--HPAQKPTNPEPPSA 970

Human   536 ---RTKRP--HMEPRTRRG---------PSP---------------------------------- 552
               :..||  .:.|....|         |||
  Fly   971 VEQQLHRPVLILPPVVLLGGREEDRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGD 1035

Human   553 --------------------------------PASPT---------------------RKPPRLQ 564
                                            ||:||                     ::||:.|
  Fly  1036 RFCVEVIPQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQ 1100

Human   565 ----------------------------------------------------------------- 564

  Fly  1101 PIYANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPN 1165

Human   565 -------DFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 622
                   :||.|:||||||||||:|.|.:...:|||||||||.::::|||:|||..||||.|...
  Fly  1166 AGMLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVAN 1230

Human   623 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKI 687
            ...||||::|.:||||..|.|||.|:..||||||.||.|||.||:|.||.||||||||:|||.||
  Fly  1231 AMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKI 1295

Human   688 IYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGL 752
            |||||||||||||.:|::|||||||||||:||||||.|||||||||||||||:.:||||||||||
  Fly  1296 IYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGL 1360

Human   753 GVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAE 817
            |||::||||||.|||||.||||||.|||.:..||.|||::.:..:::||:|.||:|||:.|:|||
  Fly  1361 GVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAE 1425

Human   818 EIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAA 882
            ::|.|.|||:..|..||.|.::||||||:....|:..|:.|||.....||||.....||..:|..
  Fly  1426 DVKKQAFFRSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLL 1490

Human   883 FRDFDFVSE 891
            |:||.:.:|
  Fly  1491 FQDFSYTAE 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKN3	XP_006717143.1	HR1_PKN_1	20..85	CDD:212012	33/60 (55%)
		HR1_PKN3_2	104..177	CDD:212022	32/94 (34%)
		HR1	177..237	CDD:294066	31/67 (46%)
		C2	335..417	CDD:301316	48/81 (59%)
		STKc_PKN	566..891	CDD:270741	204/324 (63%)
		S_TKc	566..825	CDD:214567	176/258 (68%)
Pkn	NP_001097237.1	HR1_PKN_1	131..194	CDD:212012	33/60 (55%)
		HR1_PKN_2	243..309	CDD:212013	28/67 (42%)
		HR1_PKN_3	340..414	CDD:212015	35/73 (48%)
		C2	530..611	CDD:301316	48/80 (60%)
		STKc_PKN	1174..1499	CDD:270741	204/324 (63%)
		S_TKc	1174..1433	CDD:214567	176/258 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149247
Domainoid	1	1.000	70	1.000	Domainoid score	I9545
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241576at33208
OrthoFinder	1	1.000	-	-		FOG0001458
OrthoInspector	1	1.000	-	-		otm41202
orthoMCL	1	0.900	-	-		OOG6_103771
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X914
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740