Protein Alignment PKN3 and Pkn3

DIOPT Version :10

• Sequence 1: XP_006717143.1
• Gene: PKN3 / 29941
• HGNCID: 17999
• Length: 896
• Species: Homo sapiens
• Sequence 2: XP_006233834.1
• Gene: Pkn3 / 296619
• RGDID: 1305921
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 888
• Identity: 745/888 - (83%)
• Similarity: 791/888 - (89%)
• Gaps: 11/888 - (1%)

Human    10 QGGNLWPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQL 74
            :|....|...|..||||||:||||||||||||||:||:||||||||||||||||||:||||||||
  Rat     4 EGAARQPRTGQRAPEDEKEMIRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQL 68

Human    75 HGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCA 139
            |||||||||::|||.|.   .||:.|||:|.|||.|||.||||.|||.||||||||||||.||||
  Rat    69 HGELRELHAQVLLPAPA---HEPMTSGPQPRAEQSRARLLEALHRQLEVELKVKQGAENMIHTCA 130

Human   140 SGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGA 204
            |||||||||||||||||:||||||||||||||.|||||||||||:||||||||||.:|||||.||
  Rat   131 SGTPKERKLLAAAQQMLKDSQLKVALLRMKISGLEASGSPEPGPDLLAEELQHRLRIEAAVAAGA 195

Human   205 KNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVP 269
            |||||||..:|.||||||||||||||||||||||||||||.|||:|||.|.||||||||||.|:.
  Rat   196 KNVVKLLGGQRIQDRKALAEAQAQLQESSQKLDLLRLALELLLERLPPTHSLRSRVTRELRMAML 260

Human   270 GYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELA 334
            |.|||.||.|||.|||||||||||||::||..||||||.|.||:|||||||||:::.|||.||||
  Rat   261 GNPQPLGTLVKPIALTGTLQVRLLGCKELLATVPGRSPMAVLAASPSEGWLRTRSRQQRGGGELA 325

Human   335 SEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFL 399
            ||||||||||||||||||||.|||:||||.|.|.|:|||||||||||||||||||||||:||:||
  Rat   326 SEVLAVLKVDNRVVGQTGWGLVAEKSWDQAFSISLDRARELEIGVHWRDWRQLCGVAFLKLEEFL 390

Human   400 DNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRL 464
            |||||||||||||||.||||||||:||||||||||||.|:|||||||||||||||||.|.|||||
  Rat   391 DNACHQLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRRVFSKRRGQDFLRASQMNLSMTAWGRL 455

Human   465 VMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEP 529
            ||:||||||||||:|||||||.....  |.|..|:||||.|.||..||:|.|||||||||| |||
  Rat   456 VMSLLPPCSSPSTVSPPKGCPSAAAC--ETSSSASPSNFRPVKTLPGEDMKPPPKPPRLYL-QEP 517

Human   530 TSEETPRTKRPHMEPRTRRGPSPP--ASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYY 592
             :..||.||||||:|||  |.:||  |..||.||:||||||||||||||||||||||:|||||||
  Rat   518 -APGTPCTKRPHMDPRT--GVAPPLAALSTRNPPQLQDFRCLAVLGRGHFGKVLLVQYKGTGKYY 579

Human   593 AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQ 657
            |||||||||||.||||:||||||||||.||.||||||||||||.||||||||||||:||||||||
  Rat   580 AIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACIQTSSHACFVTEFLPGGDLMMQ 644

Human   658 IHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDR 722
            |||||||||||.||:|||||||||||||:||||||||||||||||||||||||||||||||||||
  Rat   645 IHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDR 709

Human   723 TSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 787
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||:||||.|.|.|.
  Rat   710 TSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEDEVFECIVNADVPCPH 774

Human   788 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADL 852
            |||.||||.|||||||.|||||||||:|||||||||||||||||||||||:||||||||||||||
  Rat   775 FLSAQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLARTVQPPFVPTLCGPADL 839

Human   853 RYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLE 895
            ||||||||.|||.||||.|...|:||||||||||||||:||||
  Rat   840 RYFEGEFTSLPPTLTPPVPRRSLSARQQAAFRDFDFVSKRFLE 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKN3	XP_006717143.1	HR1_PKN_1	20..85	CDD:212012	58/64 (91%)
		HR1_PKN3_2	104..177	CDD:212022	64/72 (89%)
		HR1	177..237	CDD:469609	51/59 (86%)
		C2	335..417	CDD:472691	72/81 (89%)
		PTZ00449	<485..>561	CDD:185628	44/77 (57%)
		STKc_PKN	566..891	CDD:270741	296/324 (91%)
Pkn3	XP_006233834.1	HR1_PKN_1	14..79	CDD:212012	58/64 (91%)
		HR1	95..168	CDD:469609	64/72 (89%)
		HR1	168..>226	CDD:469609	49/57 (86%)
		C2	326..413	CDD:472691	77/86 (90%)
		PHA03378	<461..549	CDD:223065	59/93 (63%)
		Protein Kinases, catalytic domain	553..877	CDD:473864	295/323 (91%)