Protein Alignment PKN3 and Pkn3

DIOPT Version :10

• Sequence 1: XP_006717143.1
• Gene: PKN3 / 29941
• HGNCID: 17999
• Length: 896
• Species: Homo sapiens
• Sequence 2: XP_030107417.1
• Gene: Pkn3 / 263803
• MGIID: 2388285
• Length: 914
• Species: Mus musculus
• Alignment Length: 907
• Identity: 739/907 - (81%)
• Similarity: 785/907 - (86%)
• Gaps: 31/907 - (3%)

Human    12 GNLWPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHG 76
            |.|.||..|..|:||||::|||||||||||||:||:||||||||||||||||||:||||||||||
Mouse    15 GQLKPGTGQRAPKDEKEMVRRAIQKELKIKEGMENMRRVATDRRHLGHVQQLLRASNRRLEQLHG 79

Human    77 ELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASG 141
            |||||||::||    |..||||.|.|:|.|||.|||..|||.|||.||||||||||||.||||||
Mouse    80 ELRELHAQVLL----PASAEPVTSEPQPRAEQSRARLSEALHRQLQVELKVKQGAENMIHTCASG 140

Human   142 TPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEP-----------------------GP 183
            |||||||||||||||:|||||||||||||||||:||||||                       ||
Mouse   141 TPKERKLLAAAQQMLKDSQLKVALLRMKISSLESSGSPEPGEASQVREGGPRWPRLRVHLRPAGP 205

Human   184 ELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLE 248
            :||||||||||.||||||.|||||||||..:|.||||||||||||||||||||||||||||.|||
Mouse   206 DLLAEELQHRLRVEAAVAAGAKNVVKLLGGQRMQDRKALAEAQAQLQESSQKLDLLRLALELLLE 270

Human   249 QLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALAS 313
            :|||.|.||||||:||..|:.|.|||.||.|||.|||||||||||||:.||.|||||||.|.||.
Mouse   271 RLPPTHSLRSRVTQELWMAMLGNPQPLGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMAVLAG 335

Human   314 SPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIG 378
            ||||.||||:::.|||.||||||||||||||||||||||||.|||:||||:|:|.|:||||||||
Mouse   336 SPSESWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISLDRARELEIG 400

Human   379 VHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKR 443
            |||||||||||||||:||||||||||||||||||||.||||||||:||||||||||||..|||||
Mouse   401 VHWRDWRQLCGVAFLKLEDFLDNACHQLSLSLVPQGRLFAQVTFCEPVIERRPRLQRQRCIFSKR 465

Human   444 RGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKT 508
            ||:||:|||||||.|||||||||:||||||||:|.|||||  |..|.:......|:||||||.||
Mouse   466 RGRDFMRASQMNLSMAAWGRLVMSLLPPCSSPNTASPPKG--RPSTAVCGTPSAASPSNFLPMKT 528

Human   509 PLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLG 573
            ...|:..|||||||||| ||| :..||.||||||:||....|:..|..|||||||||||||||||
Mouse   529 LSKEDTKPPPKPPRLYL-QEP-APGTPCTKRPHMDPRPAVVPALAALSTRKPPRLQDFRCLAVLG 591

Human   574 RGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQT 638
            |||||||||||:||||||||||||||||||.||||:||||||||||.||.||||||||||||.||
Mouse   592 RGHFGKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQT 656

Human   639 SSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 703
            ||||||||||:||||||.||||||||||||.||:|||||||||||||:|||||||||||||||||
Mouse   657 SSHACFVTEFLPGGDLMAQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQG 721

Human   704 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPG 768
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   722 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPG 786

Human   769 DTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQAL 833
            |||||||:|||:.|.|.|.||||||||.|||||||.|||||||||:|||||||||||||||||||
Mouse   787 DTEEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQAL 851

Human   834 LARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLE 895
            ||||:||||||||||||||||||||||.|||.||||...|.|||||||||||||||||:|||
Mouse   852 LARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQFLE 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKN3	XP_006717143.1	HR1_PKN_1	20..85	CDD:212012	56/64 (88%)
		HR1_PKN3_2	104..177	CDD:212022	63/72 (88%)
		HR1	177..237	CDD:469609	52/82 (63%)
		C2	335..417	CDD:472691	73/81 (90%)
		PTZ00449	<485..>561	CDD:185628	40/75 (53%)
		STKc_PKN	566..891	CDD:270741	297/324 (92%)
Pkn3	XP_030107417.1	HR1_PKN_1	23..88	CDD:212012	56/64 (88%)
		HR1	103..176	CDD:469609	63/72 (88%)
		HR1	203..>257	CDD:469609	45/53 (85%)
		C2	357..444	CDD:472691	78/86 (91%)
		STKc_PKN	584..909	CDD:270741	297/324 (92%)