DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKN3 and pkn-1

DIOPT Version :9

Sequence 1:	XP_006717143.1	Gene:	PKN3 / 29941	HGNCID:	17999	Length:	896	Species:	Homo sapiens
Sequence 2:	NP_001360642.1	Gene:	pkn-1 / 181244	WormBaseID:	WBGene00009793	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	965	Identity:	360/965 - (37%)
Similarity:	519/965 - (53%)	Gaps:	129/965 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    27 KEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPG 91
            :.|||:.:.|:||||.|...::.:.:|||....::..|...|.::..|..:|:.|.    :...|
Worm   195 RSVIRKDLTKKLKIKSGYSRIKLITSDRRQSEFLRYELSDLNEQIADLQEDLQALE----MYNSG 255

Human    92 PGPAE----------PVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKER 146
            ....:          .|.:||        ...|..|:.:|..|||||:|.|....    |.|.:.
Worm   256 AFDEDVMYLDNLEDCDVENGP--------PSKLVILQLELEKELKVKRGLEQFLR----GAPDKS 308

Human   147 KLLAAAQQMLRDSQLKVALLRMKISSLE-----ASGSPEPGPELLAEELQHRLHVEAAVAEGAKN 206
            |:...:|.:|.||:.|:|:|||:|..|.     ..|.|:...||..::|..|.|.|..:.:|::|
Worm   309 KVHGDSQSLLDDSRAKIAMLRMQIERLSQEAPAVEGEPKTKVELAIDDLIIRFHKEKLIMDGSRN 373

Human   207 VVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAA-VPG 270
            ::::|.|:|..|.||:.||......:|:|.||::|||.:....||..|..|..:..|:.:. :|.
Worm   374 MIRILRSKRKPDSKAVDEAMNSYVIASEKADLIKLALLKYASSLPLEHDHRKYLIGEINSGLIPK 438

Human   271 YPQPSGTPVKPTA---------------------LTGTLQVRLLGCEQLLTA---------VPGR 305
            .|..|.....|::                     ::|.|:|.:.||..:|:.         |||.
Worm   439 PPSLSQDRNSPSSEDGGNGTSTSRRCSFMPYSLQISGCLEVTINGCAGILSEVFERKIRKDVPGV 503

Human   306 SPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLE 370
            ....::....:.|   .|.|..||... :.||..||::|||.:|.|...::.:::|||.|.:.|:
Worm   504 PGFISVYGMDASG---KKKKSARGPNS-SEEVFCVLRIDNRFIGATELRKIVDRNWDQKFDVDLD 564

Human   371 RARELEIGVHWRDWRQLCGVAFLRLEDFLDNACH-QLSLSLVPQGLLFAQVTFCDPVIERRPRLQ 434
            |:|||:|.:.:.|.|.:||.|.::|.:.::.:.. .:.:.:.|||.:|.|..:.:||:.|:|:|:
Worm   565 RSRELQIELFYHDDRSMCGFAAVKLSNLIETSSKVGIIVPVEPQGNIFVQFKYMNPVVSRKPKLE 629

Human   435 RQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNL----------------LPPCSS--------- 474
            ||.|:|..:...|   .::..||:.|:.||:.|.                :|..||
Worm   630 RQRRLFRVKESND---GARQKLGVFAFSRLIKNRGNEPSEKFAAFTGFTPMPSSSSQHQPGTSSS 691

Human   475 -PSTISPPKGCPRTPTTLREASDPAT---PSNFLPKKTPLGEE---------MTPPPKPPRLYLP 526
             |||.|.....| ||:|.....|..:   || |.|:|:....|         ||.......|..|
Worm   692 GPSTSSSIASTP-TPSTSNSLFDKVSNHLPS-FNPRKSAKKREAREAAAVAPMTAAVAAVNLNAP 754

Human   527 QEPTSEETPRTKRPHME----PRTRRGPS--PP----------ASPTRKPPRLQDFRCLAVLGRG 575
            ....|.: |.|:..::.    |..|.|||  ||          ||....|..::.||.::|||||
Worm   755 STSNSMQ-PSTQERNLVVDEFPTDRSGPSQAPPVPAVRHIDFFASSDGAPLTVEQFRLISVLGRG 818

Human   576 HFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSS 640
            |||||:|.|...|..|||:|.|||.::|.|||:|||..||||.|......||||::|..||||:.
Worm   819 HFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNE 883

Human   641 HACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFL 705
            |..|..|:..|||||..||:|||.|.:..||.|||||||.|||:..|||||:||||||||.:|::
Worm   884 HVFFCMEYSMGGDLMRHIHDDVFDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYV 948

Human   706 KIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDT 770
            ||||||||||.:|..|:||||||||||||||||:..:||||:||||||||::||||||.||.||.
Worm   949 KIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDD 1013

Human   771 EEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQ--AL 833
            |||:||.|::.|..||.:|||:.:..:::||:|.||||||.||:|||:||:|.|||..:|:  .|
Worm  1014 EEEIFDSIISEDVRYPRYLSVESIAIMRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKL 1078

Human   834 LARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDF 888
            |.|.|:|||.|.:..|.|:..|:.|||......:..:....:|...|..|.:|||
Worm  1079 LNREIRPPFQPQIRNPEDVSNFDLEFTQEKARFSAASSTRPITEADQRLFNNFDF 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKN3	XP_006717143.1	HR1_PKN_1	20..85	CDD:212012	17/57 (30%)
		HR1_PKN3_2	104..177	CDD:212022	24/77 (31%)
		HR1	177..237	CDD:294066	20/59 (34%)
		C2	335..417	CDD:301316	28/82 (34%)
		STKc_PKN	566..891	CDD:270741	186/325 (57%)
		S_TKc	566..825	CDD:214567	162/258 (63%)
pkn-1	NP_001360642.1	HR1_PKN_1	188..253	CDD:212012	17/61 (28%)
		HR1_PKN_2	273..339	CDD:212013	26/77 (34%)
		HR1	344..410	CDD:381797	23/65 (35%)
		C2	527..>589	CDD:387358	24/62 (39%)
		STKc_PKN	809..1134	CDD:270741	186/325 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161456257
Domainoid	1	1.000	378	1.000	Domainoid score	I483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	660	1.000	Inparanoid score	I445
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241576at33208
OrthoFinder	1	1.000	-	-		FOG0001458
OrthoInspector	1	1.000	-	-		otm15049
orthoMCL	1	0.900	-	-		OOG6_103771
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X914
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930