DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HCFC2 and Lztr1

DIOPT Version :9

Sequence 1:	NP_037452.1	Gene:	HCFC2 / 29915	HGNCID:	24972	Length:	792	Species:	Homo sapiens
Sequence 2:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	147/700 - (21%)
Similarity:	247/700 - (35%)	Gaps:	200/700 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGN-EGIADELHVYNTATNQWFLPAVRGDIPPGC 72
            |.|:......|...|..|..||.::.|.:|||.| :.:.::|..:......|......|..|...
  Fly   238 WTRMLECAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPR 302

Human    73 AAHGFVCDGTRILVFGGMVEYGRYSNEL--------------YELQASRWL-WKKVKPHPPPSGL 122
            ..|..|..|:.:.:|||      |:.::              |:.|::.|: ||.       ||.
  Fly   303 YHHSAVVAGSSMFIFGG------YTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKF-------SGR 354

Human   123 PPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELEL----------QHG------ 171
            .|.||..|..::|.||.:::.|.     |.|..    |||.:.|.|          |.|
  Fly   355 QPVPRSAHGAAVYDNKMWIYAGY-----DGNAR----LNDMWTLNLTGENQWEEVDQLGDRPPTC 410

Human   172 ---------------SGVVGWSI--------------------PVTKGVV---PSPRESHTAVIY 198
                           ||..|..|                    ||.:|..   ||.|..||.|.:
  Fly   411 CNFPVAVARDAMYVFSGQSGLQITNSLFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHH 475

Human   199 CKKDSGSPKMYVFGGMCGARL-DDLWQLDLETMSWS--KPETKGTVPLPRSLHTASVIGNKMYIF 260
            .:      .:|||||...:.| :||...||::..||  :||....||..|..|.::||.:.||||
  Fly   476 DR------FLYVFGGSADSTLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHASAVICDAMYIF 534

Human   261 GGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDSQ---EDKKNSRPRPRAGHCAVA 322
            ||.|.:.....:|      :|...| ||..      .||..|..   :||:....:...|...:.
  Fly   535 GGTVDNSVRRGDT------YRFQFS-SYPK------CTLRDDFGKFFQDKQFCDIQFIVGAEEIR 586

Human   323 IGTRLYFWSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVSTVEGYL 387
            |...:.|.:.|..|.:  |..:..::......||.....||..:...
  Fly   587 ILAHIAFVAARSKYLR--NKILAAREARQQQMEKVYGVGQVDALALN------------------ 631

Human   388 LQLSTDLPYQAASSDSSAAPNMQGVRMDPHRQGSNNIVPNSINDTINSTKTEQPATKETSMKNKP 452
                       |.:.....|.:: ||:       .|..|.:....:|...|::...|:|..||
  Fly   632 -----------AGAGGDRGPMLE-VRL-------ANASPEAFEIILNYIYTDRIDLKDTYSKN-- 675

Human   453 DFKALTD----SNAILYPSLASNASNHNSHVVDMLRKNEGPHTS--ANVGVLSS-CLDVRTVIPE 510
            ....:||    :.....|.||.....:..:.::.|...|..:.:  :|:.::.. |:  :.:|.|
  Fly   676 IIILITDIYQLAGLFTMPRLAHGCIQYLDYKINKLNVLEALYNADKSNIKIIKDHCM--QFIIKE 738

Human   511 TSVSSTVSSTQTMVTQQTIKTESSSTNGAVVKDETSLTTFSTKSEVDETYALPATKISRVETHAT 575
            .:.:..|.|           :|.|..:..::.:......:.:|..:|.:|          |.:..
  Fly   739 ENFTDVVMS-----------SEFSDLDKPLLVEIIRKRLYPSKLVIDTSY----------EGNIG 782

Human   576 ATPFSKETPSNPVATVKAGERQWCDVGIFKNNTALVSQFYLLPKGKQSIS 625
            .|     ...:..|.:::..:.:||:       :||.:.:::|..|..:|
  Fly   783 TT-----LEIDLCAFLESTGKDFCDI-------SLVLEDHVIPAHKSVLS 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HCFC2	NP_037452.1	PLN02193	<2..262	CDD:177844	84/325 (26%)
		KELCH repeat	23..69	CDD:276965	12/46 (26%)
		Kelch 1	34..79		10/45 (22%)
		Kelch 2	83..130		14/61 (23%)
		KELCH repeat	127..186	CDD:276965	22/109 (20%)
		Kelch_3	136..198	CDD:290151	25/115 (22%)
		KELCH repeat	190..241	CDD:276965	18/53 (34%)
		Kelch 3	207..255		20/50 (40%)
		Kelch_3	207..253	CDD:290151	18/48 (38%)
		KELCH repeat	245..312	CDD:276965	21/69 (30%)
		Kelch_3	254..323	CDD:290151	18/71 (25%)
		Kelch 4	257..303		14/45 (31%)
		Kelch_5	312..354	CDD:290565	6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..447		9/47 (19%)
		FN3	<618..672	CDD:238020	2/7 (29%)
		FN3	678..778	CDD:238020
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	90/350 (26%)
		KELCH repeat	252..298	CDD:276965	12/45 (27%)
		Kelch_3	261..310	CDD:290151	11/48 (23%)
		Kelch_5	299..>329	CDD:290565	8/35 (23%)
		KELCH repeat	302..355	CDD:276965	14/65 (22%)
		Kelch_1	358..400	CDD:279660	14/50 (28%)
		KELCH repeat	359..407	CDD:276965	15/56 (27%)
		KELCH repeat	410..455	CDD:276965	4/44 (9%)
		Kelch_1	410..452	CDD:279660	4/41 (10%)
		Kelch_1	466..509	CDD:279660	16/48 (33%)
		KELCH repeat	467..509	CDD:276965	16/47 (34%)
		BTB	564..704	CDD:279045	29/180 (16%)
		BTB	575..707	CDD:197585	27/172 (16%)
		SPOP_C_like	707..766	CDD:269810	10/71 (14%)
		BTB	798..898	CDD:279045	6/29 (21%)
		BTB	802..902	CDD:197585	5/25 (20%)
		SPOP_C_like	902..960	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940