Protein Alignment GUSB and betaGlu

DIOPT Version :10

• Sequence 1: NP_000172.2
• Gene: GUSB / 2990
• HGNCID: 4696
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_651893.1
• Gene: betaGlu / 43746
• FlyBaseID: FBgn0270927
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 269/626 - (42%)
• Similarity: 387/626 - (61%)
• Gaps: 35/626 - (5%)

Human    26 GMLYPQESPSRECKELDGLWSF-RADFSDNRRRGFEEQWYRRPLWESG-PTVDMPVPSSFNDISQ 88
            |:|||::|.:||.:.|||:|.. |:|..| ..:|..|:|:...|.::| ..:.||||:|:|||:.
  Fly    55 GLLYPRDSETREVRSLDGMWQLVRSDPYD-PLQGIREKWFMDALRKTGREIISMPVPASYNDITT 118

Human    89 DWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADI 153
            | .||..||.|||||...:|..|....||  .||..|.|..|:||:||.:...|..|:||||::|
  Fly   119 D-NLRDHVGTVWYERTFFVPRSWKTMQRT--WLRFSSVHYSAVVWINGRNATSHSIGHLPFESEI 180

Human   154 SNLVQVGPLPSRLRITIAINNTLTPTTLPPGTI-QYLTDTSKYPKGYFVQNTYFDFFNYAGLQRS 217
            |.|:..|   ...|||:..:|.|:..|:|.|:: :..||....|    :|:..||||||||:.||
  Fly   181 SGLLSFG---GDNRITVMCDNRLSNRTIPQGSVYKVATDDGTVP----IQSYTFDFFNYAGIHRS 238

Human   218 VLLYTTPTTYIDDITVTTSVEQDS-GLVNYQI----SVKGSNL--FKLEVRLLDAENKVVA---N 272
            |.|||||..:|.|:.|||.:.::. |.::|::    |.:|..:  .:|.|:|.|.:..|.|   |
  Fly   239 VHLYTTPLLHISDLEVTTQLTKEGLGRIDYRVWLDASKEGLQIQPIQLRVQLRDKDGHVAAQQIN 303

Human   273 GTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQL---TAQTSLGPVSDFYTLPVGIRTVAVTKS 334
            .....|.|.||..:.|||||||..|.|||:|:.:|   :.:..|..:.|.|.||||||:::....
  Fly   304 KAVYHGTLLVPNATPWWPYLMHSDPGYLYNLQFELFVASNEKELESLQDTYRLPVGIRSLSWDND 368

Human   335 QFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRY 399
            ..|:||||.|..|..:|||:||||||.|..||.:|||||:|.||||:|||||||:||.||..|::
  Fly   369 SLLLNGKPLYLRGFGRHEDSDIRGKGLDNALLARDFNLLKWTGANAYRTSHYPYSEESMQFADQH 433

Human   400 GIVVIDECPGVGLAL--PQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYY 462
            ||::|||||.|.:.:  ||...|     ||..:|:::.||:|||:||.|||||||.|:.:.|..|
  Fly   434 GIMIIDECPAVNIDIFEPQLLEN-----HMSSLEQLIHRDRNHPSVVAWSVANEPRSNKQGALKY 493

Human   463 LKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFEN 527
            .:.::.:.:.:...||:|...|:|.::...|.::|::..|.|.|||.:.|..::|...|..:.::
  Fly   494 FEFLVNYVREIAHGRPLTAAINANSSSCHLAQFLDIVGFNRYNSWYQNSGRTDMILNLLTIEAQS 558

Human   528 WYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKR-RKYVVGELIWNFAD 591
            |..::.||:||.|||.:|:.|.|..|..:::||||..|..::....|:.| |.:.:||.:|||||
  Fly   559 WRDRFGKPVIQFEYGGDTMEGMHSLPAFIWSEEYQVELFSRHFKAFDELRGRGWFIGEFVWNFAD 623

Human   592 FMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANE 632
            |.|.|:.|||.|||||:|||.||||..|.:||.||:.:|.|
  Fly   624 FRTAQTITRVGGNKKGVFTRNRQPKEVAHILRRRYFALAKE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUSB	NP_000172.2	Bgal_small_N	27..631	CDD:481240	266/622 (43%)
betaGlu	NP_651893.1	Bgal_small_N	56..662	CDD:481240	266/621 (43%)