Protein Alignment GUSB and CG15117

DIOPT Version :10

• Sequence 1: NP_000172.2
• Gene: GUSB / 2990
• HGNCID: 4696
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_725851.1
• Gene: CG15117 / 37197
• FlyBaseID: FBgn0034417
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 296/642 - (46%)
• Similarity: 410/642 - (63%)
• Gaps: 41/642 - (6%)

Human    26 GMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDW 90
            |||||:||.:||.:.|||:|:|......|..:|..::||.:.|.:|.||:.||||:|:|||:.|
  Fly    47 GMLYPRESETREVRSLDGIWNFVRSDQANPTQGVRDEWYAKELSKSRPTIPMPVPASYNDITTD- 110

Human    91 RLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISN 155
            .||..||.|||:|:..:|..|::|  .|:.||.||.|..|.||:||...::||.|:|||||::::
  Fly   111 NLRDHVGTVWYDRKFFVPRSWSKD--QRIWLRFGSVHYEAYVWINGQKVVKHEMGHLPFEAEVTD 173

Human   156 LVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLL 220
            |:..|   :..|||:..:|.|..||:|.|.|   |:.........||:..||||||||:.|||.|
  Fly   174 LLSYG---AENRITVMCDNALIQTTVPQGRI---TEVPNDGGMTIVQSYTFDFFNYAGIHRSVHL 232

Human   221 YTTPTTYIDDITVTTSVEQDS--GLVNYQISVKGS------NLFKLEVRLLDAENKVVANGTGTQ 277
            ||||.|:|:::.|||::.:|:  |.|.|.:||.||      |:.:::..|.|.:..:|||.|..|
  Fly   233 YTTPRTFIEEVEVTTNLSKDATVGEVFYSVSVNGSAANEADNVLQIQANLYDKDGILVANATSDQ 297

Human   278 ---GQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLIN 339
               |:|:|..|..|||||||..|.|||.||::|.|...  .:.|.|.|.|||||::....|||||
  Fly   298 KLGGKLQVNPVKPWWPYLMHSEPGYLYQLEIKLLATND--ELLDVYRLKVGIRTLSWNSQQFLIN 360

Human   340 GKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVI 404
            |||.||.|..:|||:||||||.|..|:|:|||||:|:||||:|||||||:||.||..|.:||::|
  Fly   361 GKPVYFRGFGRHEDSDIRGKGLDNALMVRDFNLLKWIGANAYRTSHYPYSEESMQFADEHGIMII 425

Human   405 DECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAH 469
            ||||.|.   .:.|:...|..|...:|:::.||:|||:|||||:||||.:...||..|.::|...
  Fly   426 DECPSVD---TENFSQELLGKHKSSLEQLIHRDRNHPSVVMWSIANEPRTGSVSADSYFELVANF 487

Human   470 TKSLDPSRPVT---FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKK 531
            |:|||.:||:|   .|||:.   ||....:|:|..|.|.:||.:.|.|::|...:..:...|.|:
  Fly   488 TRSLDKTRPITAAIAVSNTQ---DKAGRSLDIISFNRYNAWYSNAGRLDMITQNVIDEAIAWNKR 549

Human   532 YQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRK-YVVGELIWNFADFMTE 595
            |.||||.|||||:|:.|.|..|..:::||:|..:..::....|:.|:| :.:||.:||||||.|.
  Fly   550 YNKPIIMSEYGADTLEGLHMQPAYVWSEEFQTEVFSRHFKAFDELRKKGWFIGEFVWNFADFKTA 614

Human   596 QSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQC-LENSLFT 651
            ||.|||.|||||:|||.||||:||.|||:||:.:..:.        .|| ....|||
  Fly   615 QSYTRVGGNKKGVFTRARQPKAAAHLLRKRYFALGRDL--------DQCSFPEDLFT 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUSB	NP_000172.2	Bgal_small_N	27..631	CDD:481240	290/618 (47%)
CG15117	NP_725851.1	Bgal_small_N	48..648	CDD:481240	290/616 (47%)