Protein Alignment GUSB and Y105E8B.9

DIOPT Version :10

• Sequence 1: NP_000172.2
• Gene: GUSB / 2990
• HGNCID: 4696
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_493548.1
• Gene: Y105E8B.9 / 173326
• WormBaseID: WBGene00013693
• Length: 628
• Species: Caenorhabditis elegans
• Alignment Length: 613
• Identity: 239/613 - (38%)
• Similarity: 353/613 - (57%)
• Gaps: 28/613 - (4%)

Human    27 MLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWR 91
            :|:.|::..|....|||||:|..:..:....|...||....|........|||||::||:.....
 Worm    22 LLHVQKNEIRTVDSLDGLWTFVREPHNGGDVGIVNQWNTLDLERFQNATVMPVPSAYNDLGTGSE 86

Human    92 LRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNL 156
            ||..:||||||::..:|.|   |...|.|||.||.:.:|:|::|......|.||:||||.|||..
 Worm    87 LRDHIGWVWYEKKEFVPLR---DRNMRHVLRFGSVNYFAVVYINSEKVTSHIGGHLPFEVDISAQ 148

Human   157 VQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDT---------SKYPKGYFVQNTYFDFFNYA 212
            ::.|   :..:.|:|:||||:.:|:|.|...|.:..         |:.|.|.......|||||||
 Worm   149 IKFG---AENKFTVAVNNTLSWSTIPQGDFNYQSVAPRNISGRILSRLPAGAVKNVGNFDFFNYA 210

Human   213 GLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQ 277
            |:.|||.|...|:.||.:|.:   |...:|...::.:|...:..::||::.|.|..:|..|..|:
 Worm   211 GILRSVQLMKIPSVYIQNINI---VADHTGSFFFETAVSSLDGVRVEVKMFDGEGSLVYTGNQTK 272

Human   278 GQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKP 342
            .:.::....||||..|.:..  ||||||.|...   |.::|.|....|.|||..:.||..||.||
 Worm   273 SEGQISNPKLWWPRGMGKPD--LYSLEVSLILD---GELADIYREQFGFRTVTWSDSQIFINSKP 332

Human   343 FYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDEC 407
            ||..|...|||.:|.|:||:..::.||.|||.|:|.|.:||:||||:||.|...||.||.||.|.
 Worm   333 FYCLGFGMHEDFEIIGRGFNQAIMTKDLNLLEWMGGNCYRTTHYPYSEERMFENDRRGIAVIVET 397

Human   408 PGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKS 472
            |.|||   :.|:..:.:.|::::::::.||||||:|:.||:||||.:..:.:..|.|.::.....
 Worm   398 PAVGL---KGFSKANNNLHVKMLQDMIDRDKNHPSVIAWSLANEPQTMKKESRNYFKTLVDTAHG 459

Human   473 LDPSRPVTFV-SNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPI 536
            :|.:||||.| ..:|:..|:.|..:|.||:|.||.||.|.|::..|...:......|.:.:.|||
 Worm   460 IDRTRPVTTVYGPTNFDNDQTADLMDFICVNRYYGWYIDMGYIPWINQSVYWDISLWRETFHKPI 524

Human   537 IQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKY-VVGELIWNFADFMTEQSPTR 600
            |.:||||::|.|.:|:|.:.|:|:||..::::.|...|...:.: :.||:|||||||||..:.||
 Worm   525 IVTEYGADSIPGLNQEPSVDFSEQYQNEVIQETHHAFDALVKDHTITGEMIWNFADFMTGMTTTR 589

Human   601 VLGNKKGIFTRQRQPKSAAFLLRERYWK 628
            .:||.||:|||.||.|.||:.||.||.|
 Worm   590 AVGNHKGVFTRSRQAKIAAYTLRNRYLK 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUSB	NP_000172.2	Bgal_small_N	27..631	CDD:481240	239/613 (39%)
Y105E8B.9	NP_493548.1	Bgal_small_N	22..615	CDD:481240	236/609 (39%)