DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM15B and spen

DIOPT Version :9

Sequence 1:	NP_037418.3	Gene:	RBM15B / 29890	HGNCID:	24303	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	1022	Identity:	213/1022 - (20%)
Similarity:	336/1022 - (32%)	Gaps:	332/1022 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    37 AAHKASGGAKHPVPAR-----------ARDKPRGSGSGGGGHRDGRGTGDANHRASSG--RSSGS 88
            ||...:|...||:..|           :|...|...|....|.....:..::|..:|.  :|||:
  Fly   418 AAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGN 482

Human    89 GAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYKTLLISSLSPALPAE 153
            .|...||..:.......:..|...|.........|....| |||:::....:...||...|.|..
  Fly   483 CAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGC-GSSSSSSSSSSSSGSSCLTANPVV 546

Human   154 H----------------------LEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREA 196
            |                      |:|.|||::|:.|:::..........|.|.|.|:.|.|..:|
  Fly   547 HSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKA 611

Human   197 RQHALARQLLLYDRPLKVEPVYLRGGGGSSRRSSSSSAAASTPPPGPPAPADPLGYLPLHGGYQY 261
            .:  ::.....:...::|||                                          ||
  Fly   612 LE--VSHDKHFFGCKIEVEP------------------------------------------YQ- 631

Human   262 KQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYPAVCEED 326
                                                        .|.:.|:..|||       |.
  Fly   632 --------------------------------------------GYDVEDNEFRPY-------EA 645

Human   327 LMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQG-GAYAFLKFQNLDMA 390
            .:.|...::||.||||||:..::..|||..||.:|.|.|:.||:    || .||||.::.::...
  Fly   646 ELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKK----QGLNAYAFCQYSDIVSV 706

Human   391 HRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSF 455
            .:|...|.|..:|.|.||:|:||:.||..:|:.|:....|.:.|..:|.|||::..:...:....
  Fly   707 VKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQL 771

Human   456 AYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAE--------ETRYPQQ----------YQ 502
            |.:.|:.:..||||...|||..|  ..::|:||||..|        :.:..||          |:
  Fly   772 ALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYE 834

Human   503 PSPLPVHYELLTDGYTRHRNLDAD--------------------LVRDRT--------------- 532
            .|...:........::||:|...|                    |:...|
  Fly   835 SSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAM 899

Human   533 PPHLLYSDRDRTFLEGDWTSPSKSS--------------------DRRNSLEGYSRSV------- 570
            |...|.|......:....|.|:.:|                    .|...:....::|
  Fly   900 PAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEV 964

Human   571 ---RSRSGERWGADGDRGLPKPWEERRKRRSLSSDRGRT-------THSPYEERSRT-------- 617
               |.||.|.  ..|..|....:|:.|....:::.:|..       |.:..|....|
  Fly   965 GRLRFRSSEE--VSGGAGNSTQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITG 1027

Human   618 -----KGSGQQ--SERGSDRTPERSRKENHS--------SEGTKE---SSSNSLSNSRHGAEERG 664
                 .|||..  |.|...:||    |:.|.        :|..:|   |....:.:.|...:...
  Fly  1028 GAEGFTGSGGSILSRRRCGKTP----KDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDY 1088

Human   665 HHHHHHEAADSSHGKKARDSERNHRTTEAEPKPL--------EEPKHETKKLKNLSE-------- 713
            ||||||..|...      :|...|.:.. :|.||        .:|.:...:::.:||
  Fly  1089 HHHHHHSNASGV------ESTGEHSSIN-KPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPSI 1146

Human   714 --------YAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQLKIAQRLR 770
                    ..|:|.|          ||...|:     |.|.:|:|     |.|...:..|.....
  Fly  1147 KFPGHLPSAPQSLML----------SCRRPSI-----DVGALSAL-----SSSSAFRHGIVGASS 1191

Human   771 LDQ---------PKLDEVTRRIKQGSPNGYAVLLATQATPSGLGTEGMPTVEPGLQRRLLRNLVS 826
            :||         .|...||..::|.|.:      :|..:.||.|..|:.::.|..:   ..:.||
  Fly  1192 MDQQHMMNASAAAKRRRVTTTMQQPSSS------STTNSSSGSGLGGISSLTPADE---YHHHVS 1247

Human   827 YLKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTL 873
            ..:..|.....|....|.:..||:..  ..|.||...:.|.:..|.|
  Fly  1248 RGRGHQLHSHHSHEASGGESADGSRP--GTPLCDERPEVLPTEPRRL 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM15B	NP_037418.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133		24/108 (22%)
		RRM1_RBM15B	137..218	CDD:240998	22/102 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..253		0/33 (0%)
		RRM2_RBM15B	329..413	CDD:241000	33/84 (39%)
		RRM3_RBM15B	416..491	CDD:241002	24/74 (32%)
		RRM	529..>639	CDD:330708	29/176 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..705		43/228 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	593..597		1/3 (33%)
		SPOC	712..887	CDD:311609	41/187 (22%)
		Interaction with Epstein-Barr virus BMLF1	722..890		36/161 (22%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	14/74 (19%)
		RRM3_SHARP	654..726	CDD:240796	31/75 (41%)
		RRM4_SHARP	727..803	CDD:240797	24/77 (31%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820