DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde7b and Pde11

DIOPT Version :9

Sequence 1:	NP_001334295.1	Gene:	Pde7b / 29863	MGIID:	1352752	Length:	498	Species:	Mus musculus
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	103/413 - (24%)
Similarity:	183/413 - (44%)	Gaps:	69/413 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse   108 NTTHSGEIGTKKKVKRLLSFQ-RYFHAS-------RLLRGIIPQAPLHLLDEDYLGQARHMLSKV 164
            :.||..|.......|:.::.: ..:|||       ||.|..:|.| :|....|:
  Fly   755 HNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSA-VHFRLHDF----------- 807

Mouse   165 GTWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDYHGHNPYHNAVH 229
               .||...|:   :.::|...| .:|.....:..|.:|...|.|:|:.|:::|. :..|||..|
  Fly   808 ---KFDDIHFE---DDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRH 864

Mouse   230 AADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVL 294
            |.:|.|.|...|...:.......::.:..::....||:||.|.|..|.||.:..||.|| :.|.:
  Fly   865 AFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLY-STSTM 928

Mouse   295 ENHHWRSTIGMLRE--SRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRL 357
            |:||:...:.:|..  :::||:|..:....:.:.|...||:||          |..:...:...|
  Fly   929 EHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTD----------LAVYFKKRGPFL 983

Mouse   358 ENV----------QDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGDLEQKFELEIS 412
            |:|          :.|..:..:::...|:....:.||:.|:.::.|..||:.|||:| |.||.|:
  Fly   984 ESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDME-KQELNIT 1047

Mouse   413 P--LCNQQK-DSIPSIQIGFMTYIVEPLFREWARFTGNSTLS---ENMLSHLAHNKAQWKSLLSN 471
            |  :.|::| |.:|.:|:.|:..|..|::..:|      |||   |.::..:..|:..|..|...
  Fly  1048 PIDIMNREKEDELPMMQVNFIDSICLPIYEAFA------TLSDKLEPLVEGVRDNRGHWIDLADV 1106

Mouse   472 QHRRRGSGQDLAGPAPETLEQTE 494
            ...:....|:     ||..:|.:
  Fly  1107 VKTKTSQDQE-----PEEEQQQQ 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde7b	NP_001334295.1	None
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	2/6 (33%)
		PDEase_I	859..1094	CDD:278654	69/252 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820