DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY2F and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001513.2	Gene:	GUCY2F / 2986	HGNCID:	4691	Length:	1108	Species:	Homo sapiens
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1150	Identity:	378/1150 - (32%)
Similarity:	562/1150 - (48%)	Gaps:	173/1150 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    36 LCLLSV----MSLPQQVWTLPYKIGVVGPWACDSLFSKALP-EVAARLAIERINRDPS------F 89
            |.||||    .|..:.|.|:.|...:.|    |....:.|. ..|..:|::.:|:||:      .
  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTG----DLKTRQGLAISGALTMALDEVNKDPNLLPNVYL 69

Human    90 DLSYSFEYVILNEDCQTSRALSSFISHHQMASG---FIGPTNPGYCEAASLLGNSWDKGIFSWAC 151
            ||.::        |.:....|::......:..|   ..||..|.|.||  ::..|.:..:.|:.|
  Fly    70 DLRWN--------DTKGDTVLATKAITEMICDGIATIFGPEGPCYVEA--IVSQSRNIPMISYKC 124

Human   152 VNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHG 213
            ..|...   :.|||:||.|...:|   |:.:::|:.|....::.  ||:|    :.||..|:...
  Fly   125 AEYRAS---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVW----SPVADLLKDQA 180

Human   214 LPVGVVLTTGQDSQSMR-----------------KALQRIHQADRIRIIIMCMHSALIGGETQMH 261
            ....:.:...|.....|                 :.:|......||.:.:...:|.:    ..|.
  Fly   181 TKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLV----DFMS 241

Human   262 LLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLR--------NNPKLREAYD----AVLTI 314
            .:|.|.  ....|.|:.:..|.::||   :....:.||        :|....|.::    ::|.:
  Fly   242 SMETAG--LFARGEYMVIFVDMMVYS---EREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVV 301

Human   315 TVESQEKTFYQAFTEAAARG--------EIPE---KLEFDQVSPLFGT-IYNSIYFIAQAMNNAM 367
            ......|.:.| ||:...:.        |||.   :..|.:...::.. :|:|:...|.|::..:
  Fly   302 ASTPPTKDYIQ-FTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKML 365

Human   368 KE---------------NGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWE 417
            :|               ||.....:::::...|...|  ..::.|..|:....:.:|.....:|.
  Fly   366 REETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWN 428

Human   418 LHSTYTVDMEM-------------ELLRFGGTPIHFP-GGRPPRADAKCWFAEGKICHGGIDPAF 468
            ..:....:..|             |.....|: |.:| ||..|..:..|.|| .::|... |..:
  Fly   429 NSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS-IDWPSGGEKPADEPMCGFA-NELCKKD-DTHY 490

Human   469 AMMVCLTLLIALLSINGFAYFIRRRINKIQL-IKGPNRILLTLEDVTFINPHFGSK-RGSRASVS 531
            ...|...:|..||..:|.......|..||:| |:|    ||...|...|..:.|:: ..|.:.||
  Fly   491 TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEG----LLWKIDPNEIKGYSGNEIVSSPSKVS 551

Human   532 FQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFE 596
            ........|..:.:...|:|.|             .|..|.:|:..   |...:.|.........
  Fly   552 LMSAQSYGSRWTNQFVTSTGRL-------------RGAVVRIKELK---FPRKRDISREIMKEMR 600

Human   597 MMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYL 661
            ::::|||:|||..:|...:.....:||::|::|||.||:.|:|:|||.:|.:||:.||||||.|:
  Fly   601 LLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYI 665

Human   662 HHREFV-HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSME-----ELLWTAPELLRA 720
            |:.:.| ||.|||.||||..|::|:|||:|.:   |:.:.:|.||..|     ..||.|||||
  Fly   666 HNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLH---ELRQCAENESIGEHQHYRNQLWRAPELL-- 725

Human   721 PRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPP--------PVYRPVVPP 777
             |....||..||||:|||||.|:..|..||..::...:||::.:||.|        |....::..
  Fly   726 -RNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEA 789

Human   778 EHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRER 842
            |..|...|..::.||||..|:||.|..|.|:.|....||..||:|.|:.|:|:|::||||::.||
  Fly   790 ESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTER 854

Human   843 TEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVD 907
            |..|..||.|||.||.:|||.||||.|..|..|||..:||||:|||||||||.:||.|.|::||:
  Fly   855 TRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVN 919

Human   908 LLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM 972
            .||||||:||.||..:||||||||||||||.||||.:||.|||.|||:|:|::|.:|...::.|.
  Fly   920 FLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHR 984

Human   973 PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
            |...:::|||:|:||||||||||||||||||||||||||||||.|...:||:|......|..|..
  Fly   985 PNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGG 1049

Human  1038 GYEVELRGRTELKGKGTEETFWLIG------KKGFMKPLPVPPPV 1076
            ||..|.||...:||||...|:||.|      :|..:..:.:|||:
  Fly  1050 GYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	81/462 (18%)
		ANF_receptor	75..412	CDD:279440	75/404 (19%)
		PKc_like	545..815	CDD:304357	103/283 (36%)
		HNOBA	<824..869	CDD:285003	26/44 (59%)
		CYCc	848..1040	CDD:214485	121/191 (63%)
		Guanylate_cyc	875..1062	CDD:278633	116/186 (62%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	82/453 (18%)
		ANF_receptor	48..412	CDD:279440	73/394 (19%)
		PK_GC-A_B	543..827	CDD:270944	107/305 (35%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	121/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	116/186 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9715
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810