Protein Alignment GUCY1B1 and Gyc89Db

DIOPT Version :10

• Sequence 1: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Sequence 2: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 727
• Identity: 203/727 - (27%)
• Similarity: 327/727 - (44%)
• Gaps: 142/727 - (19%)

Human     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDE--EGQFLVRIIYDDSKTYDLVAAASKVLNLNA 63
            |||.:..:::..:.:.||.|.|   :|..|:.:  ...|....||.|....|..||    |:.:.
  Fly     1 MYGMLYESVQHYIQQEYGMETW---RKVCQIVDCKHQSFKTHQIYPDKLMPDFAAA----LSAST 58

Human    64 GE----ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTD 124
            ||    .:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123

Human   125 AEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEE 189
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.::...|::.:|:.|..|...|:..|....
  Fly   124 MD-DDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLT 187

Human   190 DFYEDLDRFEENGTQESRISPY--------------TFCKAFPFHIIFDRDLVVTQCGNAIYRVL 240
            ...:....|:.......|::..              .|.:.|||.|:.|.|:.:|..|..|....
  Fly   188 VIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252

Human   241 PQLQPG---------------NC-----------------SLLSVFSLVRP-H--------IDIS 264
            ....||               .|                 ::|..|.|:|. |        ::..
  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFD 317

Human   265 FHGI-----LSHINTVFVLRSKEGLLDVEKLEC------EDEL---TGTE-----ISCLRLKGQM 310
            |...     |:....:.:..:||...:..|.|.      :||:   ||..     :..:.|||||
  Fly   318 FENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQM 382

Human   311 IYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDR 375
            .|:.:.||::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
  Fly   383 FYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIM--- 438

Human   376 LQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSV 440
                   .|.|::::|          :::.:|.|.  ||...:|              :.||||:
  Fly   439 -------FEKEEQRSD----------ELEKSLELA--DSWKRQG--------------DELLYSM 470

Human   441 LPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTD 505
            :|..:|..:|.......:.::.|:::|..::  |.:.|...:.:.||:.|..||.:   |..|.:
  Fly   471 IPRPIAERMRKSEEHVCQSFEEVSVIFIEVM--NIYDSGSNNIQDAMQAVTTLNKV---FSALDE 530

Human   506 SRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGE 570
            ...:||||||||||..||.|||.|:....||...|.|||.:|:......:.|  |.|.:||::|.
  Fly   531 EIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKVKAHALPG--VAIRVGINSGP 593

Human   571 VVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSM 635
            ||.||:|.::|||||||:|||..||.|::.:...|.:|.||     :.:.....:.:|.||.|.:
  Fly   594 VVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYT-----ALKVQKVGYKVEARGFVKV 653

Human   636 KGKKEPMQVWFL 647
            |||.|....|.|
  Fly   654 KGKGEMETYWLL 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233	48/169 (28%)
		HNOBA	207..449	CDD:462234	74/315 (23%)
		Guanylate_cyc	455..648	CDD:425528	72/193 (37%)
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	48/166 (29%)
		HNOBA	218..479	CDD:462234	73/302 (24%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	71/188 (38%)