DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GUCY1A1 and ACXB

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	75/307 - (24%)
Similarity:	132/307 - (42%)	Gaps:	67/307 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   368 GQMIYIVE------SSAILFLGSPCVDRLE--DFTGRGLY---LSDIPIHNALRDVVLIGEQARA 421
            |..||.::      |..:..|.:.|||...  .|...|::   ::|..:.::..|
  Fly   181 GLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLD---------- 235

Human   422 QDGLKKRLGKLKATLEQAHQALEEE------KKKTVDLLCSIFPCEVAQQLWQG----------- 469
                             .||.|:||      :::...||.||.|.::|:.:.|.
  Fly   236 -----------------RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETD 283

Human   470 ---QVVQAKKFSN---------VTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDV 522
               .||.|::..|         |::|::|:|.:|.:.:..:..:::.:|:.||.|||.......|
  Fly   284 SDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKV 348

Human   523 YKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVV 587
            .:::.:||.|....||.:....||.....:.:.|:....||.:.....|.||||:|||::.|||:
  Fly   349 QRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVI 413

Human   588 GVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVF 634
            |....:|.::|.:|.:||:.|:...|..::||..|...|......||
  Fly   414 GQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	23/114 (20%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	50/172 (29%)
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	24/121 (20%)
		CYCc	249..459	CDD:214485	56/209 (27%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	47/163 (29%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810