DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A1 and ACXE

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	77/278 - (27%)
Similarity:	136/278 - (48%)	Gaps:	42/278 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   370 MIYIVE-----SSAILFLGSPCVDRLEDFTGRGLYLSDIPI-HNALRDVVLIGEQARAQDGLKKR 428
            :|:|.:     :||:..:|...||.:     ..|.|:.:.| :..:.|.|:..........:|::
  Fly   180 VIFIAQGFAQFASALFSVGGMSVDIV-----HYLCLNLVGIFYRVMNDTVVRSSFLDRHQYIKEK 239

Human   429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVA---QQLWQGQVVQAKK-------------- 476
            :....|.|        :||:    ||.||.|.:::   |:..||::|.||:
  Fly   240 IWLRNARL--------QEKQ----LLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAI 292

Human   477 --FSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH 539
              ..:|::|::|:|.:|.:.:..:...::.:|:.||.|||.......|.:::.:||.|....||.
  Fly   293 QIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLS 357

Human   540 KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
            .....||....::.|.|:....||...||..|.||||:|||::||||:|....::.::|.:||:|
  Fly   358 DPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDVTIA 422

Human   605 NKFESCSVPRKINVSPTT 622
            |..||..||..:::|..|
  Fly   423 NVLESTGVPGCVHISGAT 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	23/104 (22%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	52/167 (31%)
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	24/108 (22%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	49/151 (32%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810