Protein Alignment GUCY1A1 and Gycbeta100B

DIOPT Version :9

• Sequence 1: NP_000847.2
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 690
• Species: Homo sapiens
• Sequence 2: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 203/689 - (29%)
• Similarity: 310/689 - (44%)
• Gaps: 162/689 - (23%)

Human    89 LNVALQRTLAKH-------KIKESR------KSLEREDFEKTIAEQAVAAGV-----PVEVIKES 135
            :|.||:..:.||       |||:..      :.|.|:.::..|....:.|.|     |.:.|.|.
  Fly     5 VNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILEL 69

Human   136 LGEEVFKICYEED-ENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDF 199
            .|:..|:.|.:.. :.||.|:|.|.:|||.:...|     |.........:...|..|.:|:.:.
  Fly    70 FGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDAL-----HDHLGTLYPGMRAPSFRCTEKDGEL 129

Human   200 LHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSL----------------------------- 235
            | ::|:..:.....|:.||:||.|..|:..|||:.:
  Fly   130 L-LHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193

Human   236 -----------MPPCF-------HN---------------------------------------- 242
                       :.|..       ||
  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258

Human   243 --------DC-------------------SEFVNQPYLLYSVHM--KSTKPSLSPSKP------- 271
                    ||                   ..:.:..:|:..:::  ||...:.....|
  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLC 323

Human   272 QSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFE--EYFEILTPKINQT 334
            ::.|:.|.: |||.||||.|||:.|.|:|.|..:.|::.|   ..:.|..  |..|.:.|.:...
  Fly   324 EAPLISPAT-FCKVFPFHLMFDRQMKIVQAGKAVSRVIPR---VAEENCSLIEVVEAIRPHLQLN 384

Human   335 FSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLY 399
            |..|::.:|..:|::.|:...|.:...|.:.|||||:||.|:..|||...|.|..|:|.|.:|||
  Fly   385 FENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLY 449

Human   400 LSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQ 464
            :||:|:|:|.||:||:.|:..|:..|.|.|..|...|:|..:.||.||:||..||.|:.|..||.
  Fly   450 ISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVAN 514

Human   465 QLWQGQVVQAKKFSNVTMLFSDIVGFTAIC-SQCSP---LQVITMLNALYTRFD---QQCGELDV 522
            :|...:.|..|::.:||::||.||||...| :...|   ::::.|||.|||.||   .....|:|
  Fly   515 ELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNV 579

Human   523 YKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVV 587
            |||||:||.|....||....:.||..:|.:||.||:::..| .....|:::.||:|||.|..||:
  Fly   580 YKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV-KMGSNPVQITIGIHSGEVVTGVI 643

Human   588 GVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
            |.::||||||||.|.|.::.|:..||.:||||..|||||
  Fly   644 GNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	76/190 (40%)
		Guanylate_cyc	472..643	CDD:306677	72/162 (44%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	44/164 (27%)
		HNOBA	326..516	CDD:285003	77/193 (40%)
		CYCc	496..688	CDD:214485	83/188 (44%)
		Guanylate_cyc	522..714	CDD:278633	72/162 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820