Protein Alignment GUCY1A1 and Gycalpha99B

DIOPT Version :10

• Sequence 1: XP_047306103.1
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_477088.2
• Gene: Gycalpha99B / 43493
• FlyBaseID: FBgn0013972
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 247/660 - (37%)
• Similarity: 365/660 - (55%)
• Gaps: 93/660 - (14%)

Human   135 SLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAK--------HKIK---ESRKSLER 188
            :|...:.|...:.|..|..:|..|..|..|.||.|:...:||        ||:|   ::.||...
  Fly    27 ALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCAN 91

Human   189 EDFEKTIAE------QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVV-------GGTLKDFL 240
            .|:...|.|      :|.|:.:.|     .||||:...|      ..|::       |..|::||
  Fly    92 YDYLADIQELLLKMDEASASEILV-----LLGEELITCC------CTGIIERAFRCLGTDLQEFL 145

Human   241 NSFS---TLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHV 302
            .|..   .:||    .||..    :.|...:|..:.:    :.:...:...:.:|.|.:||...:
  Fly   146 GSLDGVYDVLK----LQEED----VTDTGFVCAGEGE----LIFTSERPVIAWLLLGSLKALTRM 198

Human   303 LYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVH-----MKSTKP-SLSPSKPQ----------SS 351
            ||:.:|.:.:.|  ...|...:   .||...|.     |...:| |:|.:.|:          |.
  Fly   199 LYKVDVNIKIEP--VEGDARRY---RYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASD 258

Human   352 LVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEE-------YFEILTPK-I 408
            |.:.:|.|||.||:||:.::.:.::|.|.|..:|.       ||...:       ||:...|| :
  Fly   259 LQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLY-------KPYMADFGCQATTYFDFKRPKGL 316

Human   409 NQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGR 473
            ...|..|:......|::.:.....:|...:..:::||||::..||:::||:|||.:|.|:..|..
  Fly   317 TMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCN 381

Human   474 GLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 538
            ||::||||:|:|.|:|:|:||||||||||::|:.|:|.::|:|:.|:.:|:||.|.||..|||.|
  Fly   382 GLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAE 446

Human   539 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 603
            :|::||.|..:.||.:.:||:|||||||||:|||:.:|..||:||..||..||:.|...||||||
  Fly   447 IAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVE 511

Human   604 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 668
            |||||||||.|||:.|...|.::|.|||||::...:.::..||.||||||||:|:|.|||||.||
  Fly   512 TIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKM 576

Human   669 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVF--TPRSREELPPNFPSEIPG-- 729
            |||||||::||:||||||.|...||||||||...|....||.|  .||....||..||:  ||
  Fly   577 PRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPN--PGGT 639

Human   730 -ICHFLDAYQ 738
             .|:||::::
  Fly   640 ETCYFLESFR 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	XP_047306103.1	HNOBA	354..543	CDD:462234	74/196 (38%)
		Guanylate_cyc	549..720	CDD:425528	101/172 (59%)
Gycalpha99B	NP_477088.2	HNOB	<109..208	CDD:462233	26/121 (21%)
		HNOBA	259..451	CDD:462234	75/198 (38%)
		Guanylate_cyc	457..647	CDD:425528	110/191 (58%)