DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A1 and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	247/660 - (37%)
Similarity:	365/660 - (55%)	Gaps:	93/660 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    58 SLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAK--------HKIK---ESRKSLER 111
            :|...:.|...:.|..|..:|..|..|..|.||.|:...:||        ||:|   ::.||...
  Fly    27 ALEDEELSDDALTLTHLQMAIQLLTAPSNEDLNTAVTSLVAKYRQNWPNIHKLKLDPQTFKSCAN 91

Human   112 EDFEKTIAE------QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVV-------GGTLKDFL 163
            .|:...|.|      :|.|:.:.|     .||||:...|      ..|::       |..|::||
  Fly    92 YDYLADIQELLLKMDEASASEILV-----LLGEELITCC------CTGIIERAFRCLGTDLQEFL 145

Human   164 NSFS---TLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHV 225
            .|..   .:||    .||..    :.|...:|..:.:    :.:...:...:.:|.|.:||...:
  Fly   146 GSLDGVYDVLK----LQEED----VTDTGFVCAGEGE----LIFTSERPVIAWLLLGSLKALTRM 198

Human   226 LYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVH-----MKSTKP-SLSPSKPQ----------SS 274
            ||:.:|.:.:.|  ...|...:   .||...|.     |...:| |:|.:.|:          |.
  Fly   199 LYKVDVNIKIEP--VEGDARRY---RYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASD 258

Human   275 LVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEE-------YFEILTPK-I 331
            |.:.:|.|||.||:||:.::.:.::|.|.|..:|.       ||...:       ||:...|| :
  Fly   259 LQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLY-------KPYMADFGCQATTYFDFKRPKGL 316

Human   332 NQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGR 396
            ...|..|:......|::.:.....:|...:..:::||||::..||:::||:|||.:|.|:..|..
  Fly   317 TMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFIGSPFLDGLDGLTCN 381

Human   397 GLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
            ||::||||:|:|.|:|:|:||||||||||::|:.|:|.::|:|:.|:.:|:||.|.||..|||.|
  Fly   382 GLFISDIPLHDATREVILVGEQARAQDGLRRRMDKIKNSIEEANSAVTKERKKNVSLLHLIFPAE 446

Human   462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526
            :|::||.|..:.||.:.:||:|||||||||:|||:.:|..||:||..||..||:.|...||||||
  Fly   447 IAEKLWLGSSIDAKTYPDVTILFSDIVGFTSICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVE 511

Human   527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKM 591
            |||||||||.|||:.|...|.::|.|||||::...:.::..||.||||||||:|:|.|||||.||
  Fly   512 TIGDAYCVASGLHRASIYDAHKVAWMALKMIDACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKM 576

Human   592 PRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVF--TPRSREELPPNFPSEIPG-- 652
            |||||||::||:||||||.|...||||||||...|....||.|  .||....||..||:  ||
  Fly   577 PRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFEFELQPRDPSFLPKEFPN--PGGT 639

Human   653 -ICHFLDAYQ 661
             .|:||::::
  Fly   640 ETCYFLESFR 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	74/196 (38%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	101/172 (59%)
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	35/154 (23%)
		HNOBA	259..451	CDD:285003	75/198 (38%)
		CYCc	430..619	CDD:214485	112/188 (60%)
		Guanylate_cyc	457..647	CDD:278633	110/191 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2928
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1865
Isobase	1	0.950	-	0	Normalized mean entropy	S5432
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41877
orthoMCL	1	0.900	-	-		OOG6_106420
Panther	1	1.100	-	-	LDO	PTHR45655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780