Protein Alignment GUCY1A1 and Gyc89Da

DIOPT Version :9

• Sequence 1: NP_000847.2
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 690
• Species: Homo sapiens
• Sequence 2: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 143/570 - (25%)
• Similarity: 243/570 - (42%)
• Gaps: 141/570 - (24%)

Human   161 DFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHV 225
            |||.|...:     |........:::..|:...:.:|:...:.|...:...|..|.|.:...|..
  Fly    95 DFLQSIDNI-----HLIMRFTYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVARE 154

Human   226 LYETEVEVSLMPPCFHNDCS----------------------EFVNQPYLLYSVHMKSTKPSLSP 268
            .|..|::..::..  .||.|                      :|.|:.|:...|:.::     .|
  Fly   155 FYGLEIKAYVIES--QNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEA-----HP 212

Human   269 SKPQSSLVIPT---SLFCKTFPFHFMFDKDMTILQFGNGIRRL-------MNRRDFQGKPNFEEY 323
            |:    |.:||   .:|...|||.|:.:.||.|...|..|...       .|.:.|.| .:..:.
  Fly   213 SQ----LKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIG-THVMDL 272

Human   324 FEILTPK--------------INQTFSGIMT---------MLNMQF---------------VVRV 350
            |:...||              :...|..|.|         :|||.|               :.:.
  Fly   273 FQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKA 337

Human   351 RRWDNS-------------------VKKSS---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDF 393
            :.:..|                   .::||   |.:.|||||.||.:..:::||.||.::.|::.
  Fly   338 QEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDEL 402

Human   394 TGRGLYLSDIPIHNALRDVVLIGEQARAQ-----DGLKKRLGKLKATLEQAHQALEEEKKKTVDL 453
            .|.||||:|:..|...|::|:.|.|..::     :..::|..:|:.:||.|    :..|::..:|
  Fly   403 HGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELA----DSWKRQGDEL 463

Human   454 LCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIV-----GFTAICSQCSPLQVITMLNALYTRF 513
            |.|:.|..:|:::...:....:.|..|:::|.:::     |..:|   ...:|.:..||.:::..
  Fly   464 LYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSI---QGAMQTVNTLNKVFSAL 525

Human   514 DQQCGELDVYKVETIGDAYCVAGG------LHKESDTHAVQIALMALKMMELSDEVMSPHGEPIK 572
            |::.....||||||:|..|....|      ||.|   ||..:||..:|..:..|     .|: :.
  Fly   526 DEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAE---HACDLALRVMKKFKAHD-----MGD-VA 581

Human   573 MRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622
            :|:|::||.|.|||||.|:|||||||:.|..|::.||.|.|.||.:|..|
  Fly   582 IRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	63/263 (24%)
		Guanylate_cyc	472..643	CDD:306677	56/162 (35%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	14/70 (20%)
		HNOBA	218..476	CDD:285003	63/262 (24%)
		CYCc	457..643	CDD:214485	62/187 (33%)
		Guanylate_cyc	485..662	CDD:278633	56/159 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820