Protein Alignment GUCY1A1 and CG31183

DIOPT Version :10

• Sequence 1: XP_047306103.1
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 187/640 - (29%)
• Similarity: 274/640 - (42%)
• Gaps: 148/640 - (23%)

Human   147 YLHTLAESICKLIFPEFERLN--VALQ----RTLAKHKIKESRKSLEREDFEKTI-AEQAVAAG- 203
            |.|.:||:       |...::  |:|:    |..|:..::.|..||.::..:.|: :|..|:..
  Fly   549 YRHYIAEA-------EINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSING 606

Human   204 -----VPVEVIKESLGEEVFKICYE--EDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGR 261
                 :||.:.::|      |:..:  |.:|:.|::..:|...|.....|  |..|
  Fly   607 DRQIFIPVGMFRKS------KVAIKPVEVDNVQGLLTRSLMLELKRMKDL--QHDH--------- 654

Human   262 LEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETE-------VEVSLMPPCFHN 319
            |......|||:...||...| .||.:...||            |.|       ..:|||
  Fly   655 LVKFYGACLDQRRSFLLTEY-CPKGSLQDIL------------ENEQFQLDWMFRLSLM------ 700

Human   320 DCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFG-NGIR 383
              .:.|.....|:|..::      |....:||..:..|.|.            :.|..|| :.:|
  Fly   701 --HDIVRGMQFLHSSDIR------SHGNLKSSNCVVDSRFV------------LKITDFGLHTLR 745

Human   384 RLMNRRDFQ---GKPNFEEYF--------EILTPKINQTFSG---------------IMTMLNMQ 422
            |  .|.|.:   |..|...|:        |:|..:.|:...|               |.|.....
  Fly   746 R--TRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF 808

Human   423 FVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLE-------DFTG--RGLYLS 478
            ::.|.     :.:||.:      ::|.:|:......:..|....||       |..|  |..:..
  Fly   809 YLGRC-----AYEKSPQ------EIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAE 862

Human   479 D---IPIHNALRDVV----LIGEQARAQDGLKKRL----GKLKATLEQAHQALEEEKKKTVDLLC 532
            |   .|..|.|:.::    ...|.....|.|.||:    ..|:..:|:..|...|||||...||.
  Fly   863 DPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLY 927

Human   533 SIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGEL 597
            .:.|..||.||..||.|.|:.|..||:.||||||||||.::.:|:||:..||.|||.||......
  Fly   928 QLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENF 992

Human   598 DVYKVETIGDAYCVAGGLH-KESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSV 659
            ||||||||||||.|..||. :..:.||.:||.:||.::|........|  .:.:|:|||||:|:.
  Fly   993 DVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGAC 1057

Human   660 FAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 714
            .|||||:|||||||||:.|..|::.||.....||::|.||...|.:...||.|.|
  Fly  1058 VAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRR 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	XP_047306103.1	HNOBA	354..543	CDD:462234	51/235 (22%)
		Guanylate_cyc	549..720	CDD:425528	83/169 (49%)
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596
		PK_GC-A_B	589..883	CDD:270944	70/362 (19%)
		HNOBA	<890..938	CDD:462234	17/47 (36%)
		CYCc	917..1108	CDD:214485	93/190 (49%)