DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A1 and Ac78C

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	224	Identity:	71/224 - (31%)
Similarity:	117/224 - (52%)	Gaps:	33/224 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   438 QAHQALEEEK------KKTVDLLCSIFP----CEVAQQLWQG--QVVQAK-------KFSNVTML 483
            :.|:|:|.:|      ::|..||.||.|    .::..::::|  ..|:.:       ...||::|
  Fly   513 ETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSIL 577

Human   484 FSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLHKESDT--- 544
            |:||.|||.:.|:.|..|::.:||.|:.|||:...:....:|:.:||. |||:   ..|||.
  Fly   578 FADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVS---QFESDNWKT 639

Human   545 ---HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANK 606
               |||......|.|::...:|.......:.||||:|||||..||:|.|...:.::.|:|.:||.
  Fly   640 RPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANH 704

Human   607 FESCSVPRKINVSPTTYRLLKDC----PG 631
            .||..:|.::::|..|.:.|.|.    ||
  Fly   705 MESGGIPGRVHISEATLKCLNDAYEVEPG 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	10/37 (27%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	60/178 (34%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	10/37 (27%)
		CYCc	526..729	CDD:214485	65/205 (32%)
		Guanylate_cyc	566..753	CDD:278633	59/171 (35%)
		DUF1053	929..1020	CDD:283888
		CYCc	1353..1554	CDD:214485
		Guanylate_cyc	1381..1576	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810